Ch. 20: Emergency Preparedness Flashcards Preview

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Flashcards in Ch. 20: Emergency Preparedness Deck (40)
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1
Q

Benzodiazepine Antidote

A

Flumazenil (Romazicon)

2
Q

Cyanide Antidote

A

Hydroxocobalamin (Cyanokit)

3
Q

Nitroprusside Antidote

A

Sodium thiosulfate and sodium nitrite (Nithiodote)

4
Q

Ethanol Antidote

A

Thiamine (B1)

5
Q

5-FU, capecitabine

A

Uridine triacetate (Vistogard, Xuriden)

6
Q

Arsenic, Gold, Mercury (or lead in conjunction with calcium disodium edetate) Antidote

A

Dimercarpol

7
Q

Copper Antidote

A

Penicillamine

8
Q

Lead Antidote

A

Succimer (Chemet), DMSA

9
Q

Thallium Antidote

A

Ferric hexacyanoferrate (Prussian Blue) Radiogardese

10
Q

Sulfonylurea Antidote

A

Octreotide (SandoStatin)

11
Q

Ethylene Glycol (Antifreeze), Diethylene glycol, Methanol Antidote

A

Fomepizole (Antizol) 1st line

Ethanol (2nd line)

12
Q

Isoniazid Antidote

A

Pyridoxine (B6), BZDs, and/or barbiturates

13
Q

Iron Antidote

A

Desferoxamine (Desferal), deferiprone (Ferriprox), deferasirox (Exjade, Jadenu)

14
Q

Organophosphate Antidote

A

Atropine and pralidoxine or in combo (Duodote, ATNAA)

15
Q

MTX Antidote

A

Leucovorin (folinic acid), levoleucovorin (Fusilev), glucardipase (Voraxaze)

16
Q

Methemoglobinurea Antidote

A

Methylene blue (ProvayBlue); CI in G6PD deficiency

17
Q

Mushrooms (amatoxin-containing) Antidote

A

Silibirin (Legalon SIL), Atropine (if bradycardia)

18
Q

Napthalene (mothballs) Antidote

A

Methylene Blue (ProvayBlue)

19
Q

Neostigmine, Pyridostigmine Antidote

A

Pralidoxime (Protopam)

20
Q

Nicotine Antidote

A

Atropine (if bradycardia present)

21
Q

Petroleum Distillates (gasoline, kerosene, mineral oil, paint thinners) Antidote

A

Do not induce vomiting, keep NPO to prevent aspiration

22
Q

Rocuronium, Vercuronium, Pancuronium Antidote

A

Neostigmine (Bloxiverz)

23
Q

Rocuronium, Vercuronium Antidote

A

Sugammadex (Bridion)

24
Q

Salicylate Antidote

A

Sodium bicarbonate

25
Q

Stimulants (Amphetamines-ADHD and weight loss, cocaine, ephedrine, caffeine, Theophylline, MDMA) Antidote

A

BZDs if agitation of seizures

26
Q

TCA Antidote

A

Sodium Bicarbonate: decrease a widened QRS complex
BZDs: if agitation of seizures present
Vasopressors: for hypotension

27
Q

Valproate or Topiramate induced hyperammonemia

A

Levocarnitine (Carnitor)

28
Q

Oral NAC Product and Dosing

A

Cetylev Effervescent Tablets, Mucomyst

140mg/kg x 1 dose followed by 70mg/kg Q4h x 17 additional doses

29
Q

IV NAC Product and Dosing

A

Acetadote IV

150mg/kg IV over 60 minutes, followed by 50mg/kg IV over 4 hours, followed by 100 mg/kg over 16 hours

30
Q

Warfarin and Xa Inhibitor Antidote

A

Prothrombin Complex Concentrate (KCentra)

31
Q

Heparin Antidote

A

Protamine (1mg=100u of heparin reversal)

32
Q

Direct Thrombin Inhibitor (Pradaxa) Antidote

A

Idarucizumab (Praxbind)

33
Q

Digoxin Antidote

A

Digoxin Immune Fab (DigiFab)
40 mg vials bind ~0.5 mg of Digoxin
Max adult dose: 20 vials

34
Q

Anticholinergic Overdose Sxs

A

Red as beet: flushing
Dry as a bone: dry skin and mucous membranes
Blind as a bat: mydriasis with double or blurry vision
Mad as a hatter: altered mental status
Hot as a hare: fever

35
Q

Animal Bite Antidote

A
Rabies vaccine (RabAvert, ImovaxRabies) WITH 
Human rabies immune globulin (HyperRAB S/D, Imogam Rabies HT)
36
Q

Black Widow Spider Bite Antidote

A

Antiverin for Lactrodectus mactans

37
Q

Scorpion Sting Antidote

A

Antivenin immune FAB Centruroides (Anascorp)

38
Q

Snake Bites: eastern coral snake, Texas coral snake, copperhead snake, rattle snake Antidote

A

Crotalidae polyvalent immune FAB (CroFab) for copperhead and rattlesnake bites
Antivenin Micrurus fulvius for coral snake bites
Crotalidae Immune F(ab’)2 (Anavip) for rattlesnake bites

39
Q

Atropine can be given as an antidote/sx control in:

A

Organophosphate Poisoning
Mushrooms-if bradycardia present
Nicotine-if bradycardia present
Neostigmine-give before to prevent bradycardia

40
Q

BZDs can be given for sx management in:

A

Isoniazid
Local anesthetics (bupivacaine, mepivacaine, ropivacaine) and with other lipophilic drugs
Nicotine
Stimulant overdose