Ch 5: Innate Immunity Flashcards Preview

Immunology > Ch 5: Innate Immunity > Flashcards

Flashcards in Ch 5: Innate Immunity Deck (8)
Loading flashcards...
1
Q

CD47

A

expressed by young and healthy RBCs to avoid being phagocitized

unfortunately is expressed on human cancer cells

2
Q

What is a common downstream element of TLRs that is often activated upon dimerization with a PRR

A

NF-kB (a transcription factor)

this is key for inducing many innate and inflammatory genes, including those encoding defensins =

iNOS
chemokine
cytokines (proinflammatory) = TNF-a, IL-1 and IL-6

3
Q

Which downstream element is upregulated upon and interaction of TLR and a viral component

A

interferon regulatory factors (IRFs)

these are essential for the induction of transcription of the genes encoding IFN-a and b

4
Q

MAPK

A

a mitogen activated protein kinase

involved in directing cell8ular responses to a diverse array of stimuli such as mitogens, osmotic stress, heat shock and proinflammatory cytokines

5
Q

How is a given signal transduction pathway determined when it comes to TLR// PAMPs

A

determined by the TLR and the initial protein adaptor that binds to the cytoplasmic domain

this region = TIR domain (from Toll/IL-1 receptor)

6
Q

MyD88 Dependent signaling pathway (cell membrane)

A

Myloid differentiation factor
post TLR dimer following ligand binding

membrane bound TLRs =2/1, 4 and 5

MyD88 initiates a signalling pathway and activated NF-kB and MAPK pathways by a similar pathway activated by IL-1

7
Q

MyD88 Dependent signaling pathway (endosome)

A

Myloid differentiation factor

post TLR dimer following ligand binding

endosome bound TLRs = 7, 8 and 9 which bind microbial nucleic acids

triggers pathways that activate IRF7 which induces transcription of IFN-a and b as well as NF-kB and AP-1

8
Q

endosomal TRIF-dependent signaling pathways

A

TIR domain containing adaptor inducing IFN b factor

TLR 3 and 4 = ds RNA

Trriggers pathways that activate IRF7, IRF3, AP-1 and NF-kB