chemotherapy Flashcards by Benjamin Schmidt | Brainscape

Q

ACT drugs

A

Doxorubicin
Cyclophosphamide
Paclitaxel

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Q

ACT schedule

A

8 weeks dox/cyclophosphamide

8 weeks paclitaxel

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Q

risks of doxorubicin

A

1% CHF

1% leukemia

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Q

TC drugs

A

Docetaxel

Cyclophosphamide

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Q

TC schedule

A

3 week cycles x 4 cycles = 12 weeks

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Q

doxorubicin mechanism

A

intercalates with DNA leading to inhibition of topoisomerase

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Q

cyclophoshamide mechanism

A

mustard gas - cross links DNA

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Q

Paclitaxel mechanism

A

targets tubulin

inhibits the mitotic spindle

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Q

docetaxel mechanism

A

inhibits the mitotic spindle

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Q

5FU mechanism

A

pyrimidine analog - blocks pyrimidine synthesis

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Q

Oxaliplatin mechanism

A

cross links DNA -> double strand breaks

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Q

Cisplatin mechanism

A

cross links DNA -> double strand breaks

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Q

Gemcitabine mechanism

A

nucleoside analong - blocks DNA synthesis

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Q

CROSS regimen

A

carboplatin paclitaxel

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Q

irinotecan mechanism

A

inhibits topoisomerase

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