Cholinergic presynaptic modifiers Flashcards Preview

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Flashcards in Cholinergic presynaptic modifiers Deck (10)
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1
Q

Acetylcholine synthesis

A

Acetyl-CoA + choline → Acetylcholine via Choline Acetyltransferase (ChAT)

2
Q

Presynaptic inhibitors

A

Hemicholinium

Vesamicol

Botulinum toxin

Latrotoxins

3
Q

Hemicholinium

A

inhibits choline uptake presynaptically

4
Q

Vesamicol

A

Inhibits VMAT

5
Q

Botulinum toxins

A

Cleave SNAREs and SNAPs, inhibits release

6
Q

Latrotoxins

A

Increase presynaptic release, spider toxins.

7
Q

Ganglion blockers

A

Nicotine at high doses

Hexamethoinum and Tetraethylammonium

Mecamylamine and Trimethaphan

8
Q

Hexamethonium and Tetraethylammonium

A

Quaternary amines, poorly absorbed

9
Q

Mecamylamine and Tetraethylammonium

A

Tertiary amines, better absorbed, also more penetration to CNS.

10
Q

Effects of ganglion blockers

A

nonspecific inhibition of both the sympathetic and parasympathetic

Vasodilation and hypotension

Tachycardia

mydriasis

constipation, urinary retention,
xerostomia, and anhydrosis.

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