Cirrhosis

Question 1

development of fibrosis of liver with formation of regenerative nodules; results in impairment of synthetic, metabolic and hemodynamic functions of the liver

Answer 1

cirrhosis

Question 2

Gold standard for diagnosis of cirrhosis

Answer 2

biopsy

Question 3

T/F Early fibrotic changes are reversible, as progression occurs the changes become irreversible

Answer 3

true

Question 4

Levels fall as cirrhosis worsens

Answer 4

albumin

Question 5

Levels rise as cirrhosis worsens

Answer 5

bilirubin

Question 6

Why does prothrombin time increase with cirrhosis?

Answer 6

ability of cirrhotic liver to synthesize clotting factors diminishes

Question 7

What happens to sodium levels when there is ascites and high levels of ADH?

Answer 7

hyponatremia

Question 8

usually the first hematologic abnormality of cirrhosis; secondary to portal hypertension and attendant congestive splenomegaly

Answer 8

thrombocytopenia

Question 9

Increased blood pressure in the portal vein due to increased resistance to the blood passing through the vessels in the liver

Answer 9

portal hypertension

Question 10

Treatment of portal hypertension

Answer 10

remove ascitic fluid, portal shunts, liver transplant

Question 11

Spectrum of potentially reversible neuropsychiatric abnormalities

Answer 11

hepatic encephalopathy

Question 12

neurotoxin that precipitates hepatic encephalopathy

Answer 12

ammonia

Question 13

Treatment of hepatic encephalopathy

Answer 13

lactulose, enemas, correct hypokalemia