Clinical Questions/Buzzwords Flashcards
What does the detection of HbS without any HbA indicate in an anaemic patient?
Sickle cell anaemia
What does the detection of HbS, where HbA is also present, indicate?
Sickle cell trait
What does a disproportionate reduction in MCV compared to haemoglobin levels indicate?
A haemooglobinopathy trait eg Thalassemia
What does a disproportionate reduction in MCV compared to haemoglobin levels indicate, with raised HbA2?
Beta thallasemia trait
What do you call red cells with a loss of central pallor?
Spherocytes
What condition is most likely if a patient has spherocytes on blood film and a family history of haemolytic anaemia?
Hereditary Spherocytosis
How do you treat asymptomatic iron deficiency?
Oral iron
What is the treatment for autoimmune haemolytic anaemia?
Steroids and folic acid
What is the most important diagnostic test to do in a patient who is strongly suspected to have an acute leukemia?
Immunophennyotyping to determine lineage
A 58 year old lady with a family history of hypothyroidism and atrophic gastritis presents with fatigue, macrocytosis and pancytopenia.
pernicious anaemia
A 25 year old male has recurrent admissions to hospitals with pain in his legs and chest wall. On one occasion, he became extremely breathless and required a red cell exchange transfusion.
Sickle cell anaemia
A 21 year old girl has a history of heavy periods and investigations indicate a defect in primary haemostasis. Her blood count is normal
Von Wilebrands disease
What is the theraputic target of rituximab?
CD20 (expressed on B cells and B cell lymphomas)
What is the theraputic target of imantinib?
Tyrosine Kinase inhibitor than inhibits the BCR - ABL 1 protein seen in chronic myeloid leukemia
What is the theraputic target of aspirin?
Irreversible inactivator of cyclooxygenase
