Clot lysis (Drugs) Flashcards Preview

Mechanism of Drug Action (Drugs) > Clot lysis (Drugs) > Flashcards

Flashcards in Clot lysis (Drugs) Deck (14)
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1
Q

What are the fibrinolytic drugs?

A
  1. Streptokinase
  2. Anistreplase
  3. Alteplase
  4. Duteplase
2
Q

What is the function of streptokinase?

A

Activates plasminogen activator and causes generation of plasmin. Plasmin degrades fibrin in clots.

3
Q

What is the function of anistreplase?

A

Combination of plasminogen and anisoylated streptokinase. Causes generation of plasmin which breaks down fibrin in clots.

4
Q

What is the function of alteplase/duteplase?

A

Promotes lysis of plasminogen to plasmin, which breaks down fibrin in clots.

5
Q

What are the platelet function inhibitors?

A
  1. Clopidogrel
  2. Glycoprotein IIb/IIIa receptor inhibitors
6
Q

What is the function of clopidogrel?

A

Inhibits platelet aggregation by inhibiting ADP binding to platelets.

7
Q

What are the glycoprotein IIb/IIIa receptor antagonists?

A

Eptifibatide: Cyclic heptapeptide inhibitor

Tirofiban: Non-peptide inhibitor

Abciximab: Monoclonal antibody

8
Q

What are the anticoagulants?

A
  1. Heparin
  2. Warfarin
  3. Dabigatran
  4. Rivaroxiban
9
Q

What is the function of IIb/IIIa inhibitors?

A

Antagonises IIb/IIIa inhibitors which are important in the formation of fibrinogen bridges between platelets.

10
Q

What is the function of heparin?

A

Binds to and activates antithrombin III, causing inactivation of crucial clotting factor thrombin.

11
Q

What is the function of warfarin?

A

Inhibits clotting factors II, VII, IX and X.

12
Q

What is the function of dabigatran?

A

Thrombin inhibitor.

13
Q

What is the function of rivaroxaban?

A

Clotting factor Xa inhibitor.

14
Q

How can excess bleeding from antithrombotic drugs be treated?

A
  1. Aminocaproic acid (plasminogen inhibitor)
  2. Tranexamic acid