Complex Genetic Disorders Flashcards

1
Q

What are the three types of obesity?

A

Syndromic, Monogenic and Common

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2
Q

What is syndromic obesity commonly accompanied by?

A

Mental Retardation

Dysmorphic features

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3
Q

Describe the action of leptin.

A

Leptin is produced by adipocytes and travels to the brain to let the brain know how much fat is stored in the adipose cells and thus regulates feeding

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4
Q

What are some features of leptin deficiency?

A

Low thyroid function
Immune problems
Incomplete/lack of puberty

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5
Q

What is the treatment for leptin deficiency?

A

Recombinant leptin

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6
Q

Name some genes that cause monogenic obesity.

A

POMC
PCSK1
MC4R
MRAP2

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7
Q

What are Genome Wide Association Studies used for in relation to obesity?

A

To identify single nucleotide polymorphisms that are associated with obesity e.g. FTO

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