Connective tissue Flashcards Preview

Organ histology > Connective tissue > Flashcards

Flashcards in Connective tissue Deck (29)
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0
Q

True or false; non-sulfated GAGs holds a lot of water

A

true

1
Q

What is larger sulfated GAGs or non-sulfated GAGs

A

non-sulfated

2
Q

Which type of collagen makes up ~90% of total body collagen

A

type 1

3
Q

True or false; collagen 1 is known for great tensile strength and stretching capabilities

A

false; does have great tensile strength but doesn’t stretch

4
Q

What vitamin is crucial for collagen formation?

A

Vitamin C - not enough = scurvy

5
Q

True or false; elastic which can stretch 150% of resting length decreases as we age

A

true

6
Q

Marfan’s syndrome is an hereditary condition effecting what kind of ct?

A

elastic fibers

7
Q

What kind of ct is the same as collagen 3

A

reticular

8
Q

True or false; reticular fibers which typically last ~3 days are not affected by aging

A

true

9
Q

What is the first fiber produced during wound healing

A

reticular

10
Q

What are fibroblast typically derived from? When would they divide?

A

from mesenchyme cells

primarily during wound healing

11
Q

What is the structural purpose of fibroblasts

A

produce and maintain matrix

12
Q

What is the purpose of fibroblast in healing?

A

Produce growth factors and scar formation

13
Q

True or false; fibroblast have some defensive function

A

true - produce cytokines and enzymes - can phagocytize is needed

14
Q

What is a mature less active fibroblast? What can it produce?

A

fibrocyte

hyloronic acid, ground substance, reticular fibers

15
Q

What possesses features of fibroblasts in smooth muscle

A

myofibroblasts

16
Q

True or false; adipocytes function in lipid storage and produce leptin

A

true

17
Q

True or false; plasma cells are typically found in the blood

A

false

18
Q

What are macrophages derived from?

A

monocytes

19
Q

Large cells with an indented or kidney bean shaped nucleus often containing residual bodies in cytoplasm best describes what?

A

macrophages

20
Q

True or false; on top of phagocytizing macrophages act as APCs and create foreign body giant cells

A

true

21
Q

What is a foreign body giant cell

A

permanent fusion of many macrophages

22
Q

Mast cells - which are large cells containing cytoplasmic granules are derived from what?

A

a bone marrow precursor

23
Q

True or false; histamine increases permeability - increases blood flow (vasodilation) and contracts smooth muscle

A

true

24
Q

What is heparin? What is its effect?

A

Primary mediator of inflammation in an allergic reaction

switches off histamine by binding to it

25
Q

What is an ECF? What do they do?

A

Eosinophil chemotactic factor

attracts eosinophils

26
Q

What do eosinophils do? What attracts them?

A

inhibit leukotrienes - inhibit mast cell degranulation - limit the effects of histamine and leukotrienes

ECF (eosinophil chemotactic factor)

27
Q

What are NCFs? What do they attract?

A

neutrophil chemotactic factor

attracts neutrophils

28
Q

What effect does leukotriene have?

A

Same as histamine - but much more powerful (1000x) - will also extend and amplify histamine’s effects