CV development and defects wk2 Flashcards Preview

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Flashcards in CV development and defects wk2 Deck (32)
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1
Q

Heart develops from __________ mesoderm.

A

splanchnic

2
Q

5 components of the early developing heart tube:

A
  1. truncus arteriosus
  2. bulbus cordis
  3. ventricle
  4. atrium
  5. sinus venosus
3
Q

__________ septum forms the foramen ovale, ___________ septum forms the valve associated with the FO.

A

Secondary

Primary

4
Q

Bulbar and truncal ridge tissues (from neural crest mesenchyme) give rise to?

A

aorticopulmonary septum

5
Q

Three parts of the interventricular septum:

A
  1. muscular from myoblasts

2. membranous – endocardial cushions + aorticopulmonary septum

6
Q

Aortic sac contributes to?

A

aortic arch

brachiocephalic trunk

7
Q

Left 4th aortic arch –> ?

A

aortic arch

8
Q

Right 4th aortic arch –> ?

A

right subclavian artery

9
Q

Left 6th aortic arch (proximal)–> ?

A

proximal left pulmonary artery

10
Q

Left 6th aortic arch (distal) –> ?

A

ductus arteriosus –> ligamentum arteriosum (after birth)

11
Q

Right 6th aortic arch (proximal) –> ?

A

proximal right pulmonary artery

12
Q

Right 6th aortic arch (distal) –> ?

A

degenerates

13
Q

Umbilical vein –> ?

A

hepatic ligamentum teres (round ligament of the liver)

14
Q

Ductus venosum –> ?

A

ligamentum venosum

15
Q

Umbilical arteries (distal)–> ?

A

medial umbilical ligaments

16
Q

Umbilical arteries (proximal) –> ?

A

superior vesical arteries (supply urinary bladder)

17
Q

Left to right shunts - cyanosis several months to years after birth “blue kids”:

A
  1. atrial septal defect
  2. ventricular septal defect
  3. Patent ductus arteriosus
18
Q

Right to left shunts, cyanosis early in postnatal life “blue babies”:

A
  1. Tetralogy of Falllot
  2. Transposition of the Great arteries
  3. Truncus arteriosus
19
Q

Excessive resorption of the primary septum

or

incompetent foramen ovale due to hypoplastic growth of secondary septum

A

Atrial septal defect

20
Q

Most common congenital heart abnormality:

A

Ventricular septal defect

**90% involve membranous portion

21
Q

Associated with maternal rubella:

A

Patent ductus arteriosus

22
Q

“Machinery-like” murmur…

A

patent ductus arteriosus

23
Q

4 defects in Tetralogy of Fallot:

A
  1. Ventricular septal defect
  2. pulmonary stenosis
  3. overriding (large) aorta
  4. right ventricular hypertrophy
24
Q

Malformation common in type 1 DM mother:

A

Transposition of the Great Arteries

25
Q

common aorticopulmonary outlet receives blood from both ventricles

due to failure of bulbar and truncal ridges to develop

A

Truncus arteriosus

26
Q

asymmetrical division or spiraling of the aorticopulmonary septum

A

aortic or pulmonary stenosis and atresia

27
Q

BP higher in upper extremities

A

postductal coartation of the aorta

28
Q

patent ductus arteriosus and cyanosis in LE

A

preductal coarctation of the aorta

29
Q

PDA
pulm stenosis
vent septal defect

A

maternal rubella

30
Q

deletion of 22q11
Tetralogy of Fallot
Truncus arteriosus

A

DiGeorge syndrome

31
Q

CV abnormalities associated with trisomy 21

A

atrial septal defect

ventricular septal defect

32
Q

15q21.1
5q23.31
FBN1 gene
fibrillin-1 glycoprotein abnormality

Aortic stenosis

A

Marfan syndrome