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Flashcards in Depression Deck (14)
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1
Q

Tricyclic Antidepressants (TCAs)

A

Amitriptyline (Elavil)

Nortriptyline (Pamelor)

2
Q

Amitriptyline (Elavil)

Nortriptyline (Pamelor) is used

A

Mainstay for depression treatment

3
Q

MOA for Amitriptyline (Elavil)

Nortriptyline (Pamelor)

A
  • Block reuptake of norepinephrine and serotonin into presynaptic nerve terminate
  • Increase actions of both neurotransmitters
  • Block Ach receptors
4
Q

Adverse effects of Amitriptyline (Elavil)

Nortriptyline (Pamelor)

A
  • No known antidote for overdose

- Estimated 70% TCA overdoses died before reaching hospital

5
Q

Monoamine Oxidase Inhibitors (MAOIs)

A

Phenelzine (Nardil)

6
Q

Used for Phenelzine (Nardil)

A

Effective but seldom used due to serious adverse effects

7
Q

Phenelzine (Nardil) MOA

A
  • Bind irreversibly to MAO

- Intensify actions of endogenous epinephrine, norepinephrine, serotonin, dopamine

8
Q

Phenelzine (Nardil) adverse effects

A

Orthostatic hypotension

9
Q

Nursing Concerns Phenelzine (Nardil)

A

Common drug and food interactions

Avoid food containing tyramine

10
Q

Selective Serotonin Reuptake Inhibitors (SSRIs)

A

Fluoxetine (Prozac)

11
Q

Fluoxetine (Prozac) is used for

A
  • Second generation antidepressant

- Effective and low incidence of serious side effects

12
Q

MOA of Fluoxetine (Prozac)

A
  • Block uptake of serotonin at neuronal presynaptic membrane

- Enhance action of serotonin

13
Q

Adverse Effects Fluoxetine (Prozac)

A
  • GI upset
  • Anorexia
  • Sexual dysfunction
14
Q

Nursing concerns for Fluoxetine (Prozac)

A
  • Full therapeutic effects appear in 2-6 weeks

- Avoid food containing tyramine for interaction