Dermatopathology Flashcards Preview

Dermatology > Dermatopathology > Flashcards

Flashcards in Dermatopathology Deck (102)
Loading flashcards...
1

Functions of the Skin

Prevent fluid loss
Protection barrier
Area for heat exchange
Protects against invading microorganisms
Neurological receptor relay system: touch, pressure, temp, pain
Vitamin D synthesis

2

Four Types of Skin Cells

Keratinocytes
Melanocytes
Merkel's cells
Langerhans's cells

3

What is the predominant cell of the epidermis?

Keratinocytes

4

What happens to the keratinocytes as they move superficially?

Change size
Change shape

5

What is keratin essential for?

Protective function of the skin
Is the structure protein of hair & nails

6

Five Layers of Keratinocytes

Stratum germinativum OR stratum basale
Stratum spinosum
Stratum granulosum
Stratum lucidum
Stratum corneum

7

Define Stratum Germinativum or Stratum Basale

Single layer of columnar cells, undergo mitosis, no migration

8

Define Stratum Spinosum

Two to four layers, cells differentiate

9

Define Stratum Granulosum

Only a few layers, most differentiated

10

Define Stratum Lucidum

Thin, transparent, layer mostly confined to the palms of the hand & soles of feet, transitional cells

11

Define Stratum Corneum

Many layers, dead squamous-type keratinized cells

12

Where are melanocytes located?

At or in the basal layer

13

What is the primary function of melanocytes?

Protect from UV rays

14

What do merkel cells function as?

Mechanoreceptors: touch receptors

15

Where are Langerhans' cells located?

Scattered in the supra basal layer of the epidermis

16

What are Langerhans' cells responsible for?

Recognizing foreign antigens harmful to the body

17

Define Dermis

Connective tissue layer separating the epidermis from the subcutaneous fat layer

18

What is the dermis mostly composed of?

Collagen
Variety of immune cells
Nerves
Blood vessels

19

What does the subcutaneous tissue consist of?

Primarily fat & connective tissues that lend support to the vascular & neural structures supplying the dermis & epidermis

20

Examples of Skin Appendages

Sweats glands
Sebaceous glands
Hair Nails

21

2 Types of Sweat Glands

Eccrine (Merocrine)
Apocrines

22

Location of Eccrine/Merocrine Sweat Glands

Entire body surface
Originate in dermis & open directly to the skin surface

23

Primary Function of Eccrine/Merocrine Sweat Glands

Transport sweat to body surface to regulate body temperature

24

Location of Apocrine Sweat Glands

Deep dermal layer

25

Characteristics of Apocrine Sweat Glands

Open through hair follicle
Secrete an oily substance

26

Where are sebaceous glands located?

Over entire skin surface except for the palms, soles, and side of feet

27

What do sebaceous glands secrete?

Sebum: lipids, cholesterol, & other substances

28

Function of Sebaceous Glands

Lubricate hair & skin

29

What does the hair structure consist of?

Hair follicle & hair shaft
Sebaceous gland
Hair muscle (arrector pili muscle)
Apocrine gland (sometimes)

30

What determines hair color?

Melanocytes within the bulb