Developmental Pathways in Cancer Flashcards Preview

HMS Oncology > Developmental Pathways in Cancer > Flashcards

Flashcards in Developmental Pathways in Cancer Deck (4):
1

Shh signaling

2

Invasion and Metastasis Diagram

3

Targeting CSCs

Wnt blockade!

4

Vismodegib

Smoothened inhibitor. Effective anti-cancer drug for patients with Shh pathway mutations in Shh or in Patched, usually resulting in basal cell carcinoma. Also useful for treating Patched LOF mutations.

 

WARNING: Teratogen, mandatory pregnancy testing and stringent contraception.