Developmental Pathways in Cancer Flashcards Preview

HMS Oncology > Developmental Pathways in Cancer > Flashcards

Flashcards in Developmental Pathways in Cancer Deck (4)
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1
Q

Shh signaling

A
2
Q

Invasion and Metastasis Diagram

A
3
Q

Targeting CSCs

A

Wnt blockade!

4
Q

Vismodegib

A

Smoothened inhibitor. Effective anti-cancer drug for patients with Shh pathway mutations in Shh or in Patched, usually resulting in basal cell carcinoma. Also useful for treating Patched LOF mutations.

WARNING: Teratogen, mandatory pregnancy testing and stringent contraception.