Diabetic Nephropathy

Question 1

By time have diabetic nephropathy, usually also will have…

In type 1

Answer 1

Diabetic retinopathy
If absent worry some other process

If type two not necessarily retinopathy

Question 2

Screen for nephropathy

Answer 2

Type 1 from 5 yrs… If less that this check for active urinary sediment and lupus serology and consider biopsy
Type 2from diagnosis

Question 3

Normal urine ACRs

Answer 3

Male 2.5 to 25 mg/mol
Female 3.5-35 mg/nmol

Once have it need another 1-2 checks over a three month period

Question 4

Microalbuminuria is a major risk factor for …

Answer 4

CVD

Question 5

Trials for ace in type two diabetes and ACE

Answer 5

DETAIL - enalapril vs telmisartan

ADVANCE - perindopril vs placebo

Question 6

VA NEPHRON trial

Answer 6

Diabetic nephropathy
Losartan and placebo vs loser tan plus losinopril

Not protective
Increase risk AKI and hyperk

Question 7

On target

Answer 7

Ramipril plus telmisartan vs telmisartan alone

Question 8

Does good diabetic control slow progression diabetic nephropathy

Answer 8

Probably does