DIAZEPAM (Valium®)

Question 1

Generic/Trade Name

DIAZEPAM

Answer 1

Valium®

Question 2

Generic/Trade Name

Valium®

Answer 2

DIAZEPAM

Question 3

DIAZEPAM (Valium®)

Classification:

Answer 3

• Anticonvulsant
• Sedative
• Benzodiazepine
• Anxiolytic

Question 4

DIAZEPAM (Valium®)

Mechanism of Action:

Answer 4

• Positive allosteric modulator for GABAA receptors –>Binds to benzo receptor site
  on chloride channels and potentiates binding and effects of GABA (increases
  intracellular Cl- concentration leading to hyperpolarization of the cell)

Question 5

DIAZEPAM (Valium®)

Onset of Action

Answer 5

• 1-5 minutes IV,
• 15-30 minutes IM

Question 6

DIAZEPAM (Valium®)

Peak Effects

Answer 6

• 10 minutes IV,
• 30-45 minutes IM

Question 7

DIAZEPAM (Valium®)

Duration of Effect

Answer 7

• 15-60 minutes

Question 8

DIAZEPAM (Valium®)

Half-Life

Answer 8

• 20-50 hours

Question 9

DIAZEPAM (Valium®)

Indications/Field Use:

Answer 9

• Major motor seizures
• Pre-medication for cardioversion
• Acute anxiety

Question 10

DIAZEPAM (Valium®)

Contraindications:

Answer 10

• Hypersensitivity

Question 11

DIAZEPAM (Valium®)

Side Effects/Adverse Reactions:

Answer 11

• Hypotension
• tachycardia,
• hallucinations,
• drowsiness,
• HA,
• amnesia,
• respiratory depression,
• blurred vision,
• N+V

Question 12

DIAZEPAM (Valium®)

ADULT Dose:

Answer 12

• Anxiety (ADULT): 2-5mg IV, IO
• Seizures (ADULT): 5-10mg IV, IO
• Amnesia (ADULT): 5-15mg IV, IO

Question 13

DIAZEPAM (Valium®)

PEDI Dose:

Answer 13

• 0.1-0.2mg/kg IV, IO; max dose 5mg

Question 14

DIAZEPAM (Valium®)

Precautions:

Answer 14

• May cause local venous irritation
• Do not give faster than 1mL/min
• Have benzo antagonist available

Question 15

DIAZEPAM (Valium®)

Drug-Drug Interactions

Answer 15

• Additive effects with CNS depressants and alcohol