Diebel Antibodies Part 1 Flashcards Preview

IHO Week 2 > Diebel Antibodies Part 1 > Flashcards

Flashcards in Diebel Antibodies Part 1 Deck (14)
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1
Q

Two varieties of light chains:

A

kappa

lamda

2
Q

The 5 kinds of H chains:

A

(gamma, alpha, mu, epsilon, delta)

3
Q

When a cell switches from making IgM to IgA, which chain swithces?

A

Heavy, light stays the same

4
Q

Portion of antibody that binds an antigen?

A

Variable domain

*both H and L chains have a V domain

5
Q

Slight differences in the amino acid sequences of antibody H chain C regions?

A

Isotypes

6
Q

Minor allelic differences in the sequence of immunoglobulins between individuals:

A

Allotypes

*similar to eye color, etc.

7
Q

Each antibody will have its unique combining region, made up of the CDR amino acids of its L and H chains; we can call this unique structure an:

A

Idiotype

8
Q

The main antibody in blood and tissue fluids. It neutralizes toxins and blood-borne viruses, binds bacteria and facilitates their destruction by activating complement and by binding them to phagocytic cells.

A

IgG

9
Q

Real role is as the dimer form in secretions, where secretory component protects it from proteolysis.

A

IgA

10
Q

First antibody to appear in the serum after
immunization, and it is very efficient at activating complement. It does not get into tissue fluids very efficiently, nor is it bound efficiently by phagocytic cells.

A

IgM

11
Q

Seems to function mainly as a receptor on naïve B

cells.

A

IgD

12
Q

The antibody which causes Type I immunopathology, also called immediate hypersensitivity or allergy. Its true importance is in resistance to worms and other parasites.

A

IgE

13
Q
Relative antibody concentrations in human serum:
IgG
IgA
IgM
IgD
IgE
A
IgG: 1000 mg/deciliter (dL =100 mL)
IgA: 200 mg/dL
IgM: 100 mg/dL
IgD: 5 mg/dL
IgE: 0.02 mg/dL
14
Q

What part of an antibody binds C1q? Why does this make IgM the best at activating complement?

A

Fc

*C1q must bind two adjacent Fc’s that are relatively close together

because IgM has 5 Fc’s at all times