Dissolution of tablet to bloodstream Flashcards Preview

Pharmacy (year one) > Dissolution of tablet to bloodstream > Flashcards

Flashcards in Dissolution of tablet to bloodstream Deck (11)
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1
Q

What is mass transfer?

A

The net movement of mass from one location to another

2
Q

What is the driving force?

A

The difference of chemical potential i.e. difference in concentrations

3
Q

Diffusion explains mass transfer in absence of additional _____

A

forces

4
Q

What is the unit for diffusion coefficient?

A

area/time

5
Q

Small molecules diffuse slower than large molecules. True or false?

A

False

6
Q

Which factors influence membrane permeability?

A

Diffusion coefficient
Partition coefficient
thickness of membrane

7
Q

Ideally, you want a drug with a high _____ and a high ______

A

permeability

solubility

8
Q

The rate of absorption of a weak acid is often higher in the intestine than in the stomach. True or false?

A

True

9
Q

The residence time in the small intestine is longer than in the stomach. True or false?

A

True

10
Q

Ions in solution can pair with ______ ions which will help them to dissolve

A

counter ions

11
Q

Diffusion reflects the change of concentration of drug over time. True or false?

A

True

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