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Cancer Risk Assessment > Dose > Flashcards

Flashcards in Dose Deck (23)
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1
Q

Exposure is _____ to establish potential hazard

A

sufficient

2
Q

Potency requires?

A

Dose response data

3
Q

“The dose makes the poison”

A

paracelsus

4
Q

routes of exposure

A

ingenstion
skin contact
inhalation
skin absorption

5
Q

Dose =

A
C x IR x AF x EF / BW
concentration
intake rate
bioavailability factor
exposure factor
body weight
6
Q

volumetric conversion factor

A

1 liter/1000 cm^3

7
Q

conversion factor for soil concentration

A

10^-6 kg/mg

8
Q

NHANES

A

National Health and Nutrition Examination Survey

9
Q

potential dose

A

amount of chemical contained in substance swallowed, inhaled or applied to skin

10
Q

potential dose compared to absorbed dose

A

absorbed will always be less.

11
Q

components of an exposure to dose conversion

A
  • concentration at the point of contact
  • calculate exposure
  • determine intake rate
  • estimate potential dose
  • calculate time-weighted dose
12
Q

gas under STP

A

mg/m^3 = ppm x MW/24.5

13
Q

inhalation default rate

A

20 m^3 air per day

14
Q

drinking default rate

A

2 L water / day

15
Q

Average daily dose (ADD)

A

average dose per day over period of interest

16
Q

Lifetime Average Daily Dose (LADD)

A

Dose potential / averaging time

17
Q

default lifetime

A

75 years

18
Q

dose (potential)

A

concentration x duration x intake rate / BW

19
Q

Exposure factor

A

for intermittent exposures

=duration/averaging time

20
Q

CPF

A

cancer potency factor

linear extrapolation from high dose animal or human studies

21
Q

1 eV = _____ Joules

A

1.6x10^-19

22
Q

1 RAD = ____ Joules

A

0.01 Joule

23
Q

1 Gy = ____ rad

A

100 Rad

Joule/kg