Drug Allergies Flashcards
1
Q
what are risk factors for drug allergies
A
chemical structure (similar structures may cause cross sensitivity) molecular weight (high molecular weight increases change) route of administration dose, duration of therapy, related exposure to drug
2
Q
what molecular mass is required for immunogenicity and what are most drugs
A
over 10,000 daltons required for immunogenicity
most drugs are less than 1,000 daltons
3
Q
low molecular weight drugs must do what before they can be immunogenic
A
bind a hapten
4
Q
serum sickness is due to what
A
soluble circulating immune complexes that form under conditions of antigen excess
5
Q
how does serum sickness present
A
fever, malaise, lymphadenopathy
6
Q
when does serum sickness present
A
7-14 days following exposure
7
Q
what are common causes of serum sickness
A
cephalosporins, antivenim (equine serum leads to allergic reaction)
8
Q
drug fever onset is when
A
7-10 days
9
Q
what are common agents that cause drug fever
A
amphotericin D, antimicrobials
