Drug Interactions Flashcards Preview

Year 3: CSP & PH > Drug Interactions > Flashcards

Flashcards in Drug Interactions Deck (13)
1

Outline the phases of drug trials

Phase 1 = safety & toxicity in health subjects
Phase 2 = first assessment in patients, dose range identified
Phase 3 = tests efficacy in wider patient population
Phase 4 = post-marketing surveillance of adverse effects, efficacy, safety and toxicity

2

What is involved in phase 1 of drug trials?

Healthy human subjects to assess SAFETY and TOXICITY. About 100 subjects.

3

What is involved in phase 2 of drug trials?

DOSE RANGE IDENTIFIED in patients, monitor pharmacokinetics/dynamics. Usually about 500 subjects.

4

What is involved in phase 3 of drug trials?

TESTS EFFICACY, used in the wider patient population. Usually 2000 patients with multi-centre trials

5

What is involved in phase 4 of drug trials?

Post-marketing surveillance: efficacy, safety, toxicity and adverse effects monitored

6

Which drugs can interact with warfarin?

Cimetidine, erythromycin, ciprofloxacin, sulphonamides

7

Which drugs can interact with theophylline?

Cimetidine, erythromycin --> can cause convulsions/arrhythmias

8

Which drugs can interact with digoxin?

Amiodarone, verapamil, quinidine, diuretics --> arrhythmias and heart block

9

Which drugs can interact with beta-blockers?

Verapamil and diltiazem (non-dihydropyridine CCBs) --> bradycardia and systole

10

Which drugs can interact with lithium

Thiazide diuretics --> ataxia, convulsions

11

Which drugs can interact with azathioprine/mercaptopurine?

Allopurinol --> bone marrow failure

12

Which drugs can interact with phenytoin?

Isoniazide, sulphonamides -> ataxia

COCP --> reduced effect

13

Which anti-emetic drug accelerates gastric emptying?

Metoclopramide