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Flashcards in Drug/nutrient interaction Deck (32)
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1

What is alendronate (fosamax) used for?

Bisphosphate used to prevent one resorption

2

What are the interactions that are concerning for alendronate (fosamax)?

Presence of liquids can reduce absorption up to 60% (take two hours prior to a meal)

3

What is ondansetron (zofran) used for?

Antiemetic

4

What are the concerning drug interactions with ondansetron (zofran)?

Increased absorption with increased GI transit time (with food)

5

What is ciprofloxacin used for?

Antibiotic

6

What are the concerning interactions with cipro?

Cipro can bind divalent cations (Ca, Fe, Zn etc) and impairs drug absorption

7

What is omeprazole (prilosec) used for?

PPI

8

What are the concerning interactions of omeprazole (prilosec)?

Impairs B12 absorption d/t higher pH of the stomach

9

What is colestipol (colestid) used for?

Antilipidemic agent to treat hyperlipidemia

10

What are the concerning interactions for colestipol (colestid)?

Loss of ADEK vitamin absorption

11

What is the MOA of colestipol (colestid)?

Sequesters bile salts and causes the liver to pull more cholesterol from the blood to make bile salts

12

What nutrient does cipro impair the absorption of?

Ca

13

What is the use of phenytoin (dilantin)?

Anticonvulsant

14

What is the interaction that is concerning for phenytoin (dilantin)?

Hypoproteinemia will increase the doseage of the drug d/t loss of binding proteins

15

What is ethinyl estradiol used for?

Oral contraception

16

What is the is the concerning interaction of ethinyl estradiol?

St. John's wort increases p450 enzyme, increasing the metabolism of ethinyl estradiol

17

What is the clinical use of simvastatin (zocor)? MOA?

HMG-coa reductaase inhibitor used to treat hypercholestermia

18

What is the concerning interaction for simvastatin (zocor)?

Grapefruit juice increases bioavailability of drug d/t inhibition of p450 enzyme

19

Grapefruit juice should never be taken with what types of drugs?

Statins

20

What is the therapeutic use of Li (eskaltih)?

Used to treat manic-depressive disorder

21

What is the concerning interaction of Li (eskalith)?

Li and Na can compete for binding sites in the kidney (Na/K ATPase).

Changes in Na intake will change the reabsorption of Li (increased Na, decreased Li effectiveness)

22

What is phenelzine (nardil) used for? MOA?

MAOI used for depression

Inhibits breakdown of catecholamines

23

What is the interaction the is concerning for phenelzine (Nardil)?

Tyramine can increase the release of catecholamine, increasing already high levels

Hypertensive crises

24

What is the MOA of warfarin (coumadin)?

Inhibits vit K epoxidase needed to convert prothrombin, to thrombin

25

What are the concerning interactions of coumadin?

Green leafy vegetables will increase vit K availability

26

What is the MOA of NSAIDs?

Inhibition of prostaglandin (PGE2) synthesis

27

What are the concerns of NSAIDs use?

Mucosal irritation
Decreased stomach pH

28

What is the effect of anticholinergics on the GI tract?

Block smooth muscle contraction

Decrease salivation

29

What are the concerning effets of tricyclic antidepressants?

block H1, stimuating appetite

30

What are the concerning effets of tricyclic SSRIs?

Increased serotonin, decreases appetite