Drug Quiz 7 Flashcards Preview

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Flashcards in Drug Quiz 7 Deck (89)
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1
Q

Glucagon trade

A

GlucaGen

2
Q

GlucaGen generic

A

Glucagon

3
Q

Glucagon class

A

hormone

4
Q

glucagon moa

A

breaks down glycogen to glucose, increases HR and myocardial contractility, improves AV conduction independent of beta blockade

5
Q

glucagon onset

A

5-20 min

6
Q

glucagon peak

A

30 min

7
Q

glucagon duration

A

1-2 hrs

8
Q

glucagon half life

A

varies

9
Q

glucagon indications

A

hypoglycemia without iv access; beta-blocker/ca channel blocker overose

10
Q

glucagon contraindications

A

none

11
Q

glucagon side effects

A

hypotension, dizziness, nausea, vomitting

12
Q

glucagon adult dose

A

1.0mg IM q 5-20

13
Q

glucagon pedi dose

A

0.03-0.1 mg/kg IM

14
Q

Glucagon beta-blocker OD and choking dose

A

5 mg IV

15
Q

glucagon precautions

A

check BGL before and after, only effective if glycogen stores in liver, caution in Pt’s with cardiovascular and renal disease

16
Q

glucagon interactions

A

few in ems

17
Q

thiamine class

A

vitamin b1

18
Q

thiamine action

A

converts pyruvic acid to acetyl coA in the Krebs cycle allowing for breakdown of glucose to ATP; deficiency leads to Wernicke’s encephalopathy and Korsakoff’s psychosis

19
Q

thiamine onset

A

rapid

20
Q

thiamine peak

A

varies

21
Q

thiamine duration

A

varies

22
Q

thiamine half life

A

N/A

23
Q

thiamine indications

A

administer with D50 to severe alcoholics to prevent Wernicke’s encephalopathy and Korsakoff’s psychosis

24
Q

thiamine contraindications

A

none

25
Q

thiamine side effects

A

hypotension, restlessness, cardiovascular collapse, pulmonary edema

26
Q

thiamine adult dose

A

50-100 mg iv over 5 min

27
Q

thiamine pedi dose

A

10-25 mg iv over 5 min

28
Q

thiamine precautions

A

give prior to dextrose to facilitate uptake

29
Q

thiamine interactions

A

none

30
Q

50% dextrose in water trade

A

D50

31
Q

D50 generic

A

50% dextrose in water

32
Q

d50 class

A

carbohydrate

33
Q

d50 action

A

principal form of glucose used by body to create energy

34
Q

d50 onset

A

<1 min

35
Q

d50 peak

A

varies

36
Q

d50 duration

A

varies

37
Q

d50 half life

A

n/a

38
Q

d50 indication

A

hypoglycemia

39
Q

d50 contraindications

A

none

40
Q

d50 side effects

A

tissue necrosis and phlebitis at injection site, warmth, pain, or burning at injection site

41
Q

d50 adult dose

A

25 g in 50ml IV

42
Q

d50 pedi dose

A

dilute 1:1 to make d25 and give 0.5-1.0 g/kg slow IV

43
Q

d50 precautions

A

increased ICP, check BGL before and after, administer with 100 mg thiamine if suspected deficiency

44
Q

d50 interactions

A

none

45
Q

metoclopramide trade

A

reglan

46
Q

reglan generic

A

metoclopramide

47
Q

reglan class

A

antiemetic

48
Q

reglan action

A

dopamine antagonist, sensitizes GI smooth muscle to Ach leading to gastric emptying without increased secretions

49
Q

reglan onset

A

1-3 min IV, 10-15 min IM

50
Q

reglan peak

A

1-2 hrs

51
Q

reglan duration

A

1-3 hr

52
Q

reglan half life

A

3-6 hrs

53
Q

reglan indications

A

nausea, vomitting

54
Q

reglan contraindications

A

hypersensitivity or sulfa allergies, GI bleeding, bowel obstruction or perforation

55
Q

reglan side effects

A

dystonia, sedation, drowsiness, bradycardia

56
Q

reglan adult dose

A

10-20 mg IM, 10 mg slow IV

57
Q

reglan pedi dose

A

1-2 mg/kg

58
Q

reglan precautions

A

Pt’s with CHF, hypokalemia, renal dysfunction; have benadryl ready for dystonic reaction

59
Q

reglan interactions

A

antagonized by anticholinergics, potentiated effects with other CNS depressants

60
Q

promethazine trade

A

phenergan

61
Q

phenergan generic

A

promethazine

62
Q

phenergan class

A

antiemetic

63
Q

phenergan action

A

phenothyazine derivative; depression of CTZ in medulla for antiemetic effects

64
Q

phenergan onset

A

5 min IV, 20 min IM

65
Q

phenergan peak

A

varies

66
Q

phenergan duration

A

4-6 hrs

67
Q

phenergan half life

A

10-14 hrs

68
Q

phenergan indications

A

nausea and vomitting, potentiate analgesics

69
Q

phenergan contraindications

A

hypersensitivity, coma

70
Q

phenergan side effects

A

dystonia, sedation, drowsiness, bradycardia

71
Q

phenergan adult dose

A

12.5-25mg IV/IM

72
Q

phenergan pedi dose

A

0.5 mg/kg IV/IM

73
Q

phenergan precautions

A

caution with Pt’s with impaired hepatic function, asthma, hypertension; have benadryl available for dystonic reactions

74
Q

phenergan interactions

A

alcohol and CNS depressants add to CNS depression and anticholinergic effects

75
Q

ondansetron trade name

A

zofran

76
Q

zofran generic name

A

ondansetron

77
Q

zofran drug class

A

anti-emetic

78
Q

zofran mechanism

A

serotonin R antagonist, especially at the vagal nerve terminals

79
Q

zofran onset

A

10-30 min

80
Q

zofran peak

A

unknown

81
Q

zofran duration

A

unknown

82
Q

zofran half-life

A

4 hrs

83
Q

zofran indications

A

nausea/vomitting

84
Q

zofran contraindications

A

hypersensitivity

85
Q

zofran side effects

A

diarrhea, dizziness, dry mouth, prolonged QT interval

86
Q

zofran adult dose

A

4mg over 2-5 min

87
Q

zofran pedi dose

A

0.1mg/kg over 2-5 min

88
Q

zofran precautions

A

lower risk of sedation and dystonia than other antiemetics

89
Q

zofran interactions

A

may affect clearance and half-life with inducers and inhibitors of cytochrome p-450 enzymes