Drugs affecting Hypothalamic, Pituitary, and Thyroid Function Flashcards Preview

Endocrinology > Drugs affecting Hypothalamic, Pituitary, and Thyroid Function > Flashcards

Flashcards in Drugs affecting Hypothalamic, Pituitary, and Thyroid Function Deck (24)
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1
Q

Prolactin rises during pregnancy, remains elevated until birth, falls afterwards unless the mother breastfeeds/

A

ok

2
Q

What does hyper-prolactinemia cause?

A

Galactorrhea, amenorhea, infertility –> in women

Poor libido, impotence, infertility—> men

3
Q

Treatment of a prolactinoma

A

surgery, radiation, Dope Receptor Agonist

4
Q

What is Cabergoline?

A

A high Affinity Dopa Receptor Agonist….used in treating hyperprolactinemia

5
Q

Growth Hormone release is

A

pulsatile…makes measuring it meaningless

6
Q

GH release is stimulated by what kind of blood sugar level?

A

Hypoglycemia…you grow when you’re sleeping and when you’re sleeping you’re fasting.

7
Q

Hyperglycemia and GH

A

Hyperglycemia inhibits it

8
Q

Test for GH deficiency by injecting insulin and measuring GH response

A

word

9
Q

What are the 5 viable options for measuring GH

A

1) measure GH in pooled blood samples taken over 24 hour periods.
2) Measure IGF-1 *****
3) Inject insulin
4) Use standard height charts…not effective
5) Have the pt drink a high fructose soft drink

10
Q

GH and prenatal birth

A

GH does not affect prenatal birth

11
Q

Adult GH deficiency

A

Obese, low muscle mass, low CO

12
Q

Somatotropin

A

Generic GH

13
Q

Adverse Effects of GH tx in kids

A

HTN, Papilledema, VISUAL DISTURBANCES, HA, LEUKEMIA

14
Q

AE’s of adults GH treatment

A

increased muscle and bone mass, Low fat, peripheral edema, carpal tunnel, arthralgia/myalgia

15
Q

GH excess =

A

gigantism and acromegaly

16
Q

GH excess treated with

A

Ocreotide

17
Q

Ocreotide is what

A

Somatostatin analog, given in TID injections (there is an extended release form that is given in a slow release once a month injection).

18
Q

FSH and LH

A

Can be given directly for infertility in anovulatory women, women with hypogonadism, or infertile women that are ovulating.

Only treats infertility in males, not hypogonadism

19
Q

Gosarelin

A

GnRH agonist for prostate cancer. Increases LH production initially then decreases LH (and thus testosterone) by downregulating receptors

20
Q

Menotropin

A

Purified old bitch piss. Contains LH and FSH

21
Q

Cetrorelix and Ganirelix

A

GnRH receptor antagonists that delay the LH surge so that ovulation is delayed and ova have time to develop

22
Q

Levothyroxine

A

T4. Higher doses required in kids. Can take weeks to reach new steady state levels. Monitor levels closely

23
Q

Liothyronine

A

L3. tablets or injectable

24
Q

Look at the Thyroid drugs on the sheet

A

ok