Drugs and Receptors Flashcards Preview

PoD Test 1 > Drugs and Receptors > Flashcards

Flashcards in Drugs and Receptors Deck (15)
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1
Q

What is pharmacokinetics?

A

What the biological system does to the drug

Absorption, Distribution, Biotransformation and excretion

2
Q

What is pharmacodynamics?

A

What the drug does to the biological system

Mechanisms of action and effects of drugs

3
Q

What is intrinsic activity?

A

Inherent property of the drug to impart a cellular response

Agonists have intrinsic activity

Antagonists have no intrinsic activity

4
Q

What is an inverse agonist?

A

Agents which stabilize the receptor in its inactive conformation

(Constituitively active receptors)

5
Q

How are receptors classified?

A

Based on effects and potencies of selective agonists/antagonists and molecular biology

6
Q

What is drug specificity?

A

Ability to bind or act on a particular cell type or tissue

7
Q

What is drug selectivity?

A

Ability of a drug to exert a single effect

Depends on specificity/receptor distribution

8
Q

What are three types of enzymatic receptors?

A

Protein kinases

Protein Kinase-associated receptors

Guanylyl Cyclase

9
Q

What is the largest family of physiological receptors?

A

G-protein-coupled receptors

Multiple G-protein types that have different effects

10
Q

What is the function of cAMP?

A

Regulates the activity of PKA

Inactivated by PDE

11
Q

What is the function of cGMP?

A

Regulates the activity of cGMP-dependent protein kinase (PKG)

12
Q

What is desensitization?

A

Continuous stimulation of the receptor results in downregulation of the receptor

Receptor gets recycled or degraded

Long-term administration of an agonist

13
Q

What is supersensitization?

A

Chronic administration of an antagonist

Causes decreased downregulation and when the antagonist is removed, produces an exaggerated response

14
Q

What is tachyphylaxis?

A

loss of response on repeated administration

15
Q

What are some drug actions that are not receptor-mediated?

A

Antacids

Osmotic diuretics

Cholesterol-binding resins

Antibiotics (no human receptors activated)