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Flashcards in Drugs for ILD Deck (21)
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1

Prednisone, an anti-inflammatory and immunosuppressive may lead to suppresion of what pathway? 

 

What should be monitored for?

Suppression of the HPA

 

 

Monitor for Cushing's Syndrome and Hyperglycemia 

2

What type of drug is Mycophenolate? 

 

 

What is the Black Box Warning?

Immunosupressive Drug 

 

 

Embryotoxic

3

What are the side effects of mycophenolate?

Diarrhea

leukopenia

infections 

4

What are the drug interactions of mycophenolate?

efficacy is reduced by antacids, PPIs, or drugs that enter enterohepatic circulation

 

May diminish efficacy of OCPs

5

what is the black box warning for methotrexate?

Careful use as indicated by physicians with knowledge and experience using the drug 

Deaths have been reported in using MTX

Used to treat malignancy, psoriasis and RA

6

What are some main concerns of MTX outside of the black box warning?

fetal death 

reduced elimination in renal pt's

bone marrow suppression and aplastic anemia 

hepatotoxicity with prolonged use

lung disease

diarrhea and hemorrhagic enteritis 

7

Should women of childbearing potential use MTX? 

No, not until pregnancy is excluded and they're counseled on risks 

8

The incidence and severity of acute side effects of MTX is related to what two things?

Dose

Frequency of administration

9

What are the contraindications for the immunosuppressive antimetabolite, Azathioprine?

HSN to the drug itself

Pregnant women with RA 

10

What are the two adverse reactions of Azathioprine?

Hematologic and GI issues

11

What is the black box warning for Azathioprine?

Chronic immunosuppression

increased risk of malignancy 

12

Which drug is a kinase inhibitor used for IPF?

 

What are the main contraindications?

 

Nintedanib 

 

No significant CI

13

What are some GI sx to watch for on Nintedanib?

elevated liver enzymes 

N/V/D 

GI perforation during surgery 

14

What are some hematologic concerns to watch for on Nintedanib?

arterial thromboembolic events 

bleeding 

15

Should Nintedanib be given to pregnant women?

No

16

What are the common side effects of Nintedanib?

N/V/D

elevated liver enzymes

HA

HTN 

17

Co-administration of P-gp and CYP3A4 inhibitors may increase what drug levels?

Nintedanib 

Monitor pt's closely for tolerability 

18

What are the two main indications for Azathioprine?

(besides ILD)

Renal Homotransplantation 

RA

(and ILD obviously) 

19

What are some drugs to avoid mixing with MTX?

NSAIDs (causes MTX toxicity) 

Oral Abx (interferes with enterohepatic circulation) 

Hepatotoxic drugs (accelerates hepatoxicity) 

Theophylline (decreases clearance) 

 

20

MTX is especially toxic to which two major organs?

Liver 

Kidneys 

21

Which drug is very successful in treating RA?

Mycophenolate