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Unit I M2M > Drugs- Get Them Here > Flashcards

Flashcards in Drugs- Get Them Here Deck (22)
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1
Q

Warfarin- What enzyme does it inhibit? What process is prevented? What is it used for?

A

Inhibits gamma-glutamyl carboxylase. Prevents the carboxylation of glutamate which is important in clotting factors, thus blood thinner.

2
Q

Vornistat

A

HDAC inhibitor. Prevents HDAC from silencing tumor suppressor genes, thus cancer drug.

3
Q

Gleevac

A

bcr-abl Tyrosine kinase inhibitor. Prevents dephosphorylation of tyrosine residue by competitive binding inhibiting cell proliferation. Cancer drug for Chronic Myeligenous Leukemia (CMC).

4
Q

Bortezomib

A

Protesome inhibitor. Prevents degradation of apoptotic factors. Treats multiple myeloma.

5
Q

alpha-amanitin

A

RNA polymerase II inhibitor. Binds to bridge helix (alpha helix btwn upper and lower “jaw” of enzyme) and prevents translocation of Pol II on promotor.

6
Q

Rifampicin

A

RNA polymerase II inhibitor. Blocks RNA exit channel located within beta-subunit of Pol II.

7
Q

AZT

A

Inhibitor of HIV Reverse Transcriptase

8
Q

Acyclovir

A

inhibits Viral DNA polymerase, used for Herpes Simplex Virus, and Varicella Zoster Virus

9
Q

Quinolones

A

Inhibits bacterial DNA gyrase, a topoisomerase

10
Q

Puromicin

A

An antibiotic that mimics the “acceptor” 3’ end of a tRNA that is charged with an amino acid.

Puromycin can bind in the ribosome as it is translating and covalently attach to a growing polypeptide chain,
preventing the completion of translation.

11
Q

Streptomycin

A

inhibits 30s subunit; affects initiation and elongation

12
Q

Erythromycin, and Choloramphenicol

A

inhibits 50s subunit; affects peptidyl transferase

13
Q

Tetracyclin

A

inhibits A site, affect binding of aminoacyl tRNA

14
Q

Rapamycin

A

inhibit mTor; inhibit phosphorylation of 4E-BP

15
Q

DDI

A

Inhibitor of HIV Reverse Transcriptase

16
Q

What does eIF2 kinase do?

A

It phosphorylates inactive nucleases, making them active to degrade viral mRNA

17
Q

Cyclosporin and Fk506

A

immunosuppressants that inhibit calcineurin, which inhibits NFAT from entering the nucleus and activating immune response

18
Q

Aspirin

A

anti-inflammatory agent. Inhibits phosphorylation and degredation of Inhibitor kappa B, thus preventing NF-kappa B from entering the nucleus and transcribing genes for inflammatory response

19
Q

Cisplatin

A

an alkylating agent that forms DNA adducts that disrupt DNA replication in rapidly dividing cells

20
Q

Actinomycin D

A

antibiotic that intercalates with DNA to interfere with DNA replication

21
Q

Aminoglycosides

A

cause premature termination of polypeptide synthesis at ribosome

22
Q

Microlides

A

inhibit translation in bacteria by inhibiting PTC function