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Drug Therapy Protocols (Full) > DTP Hydroxocobalamin > Flashcards

DTP Hydroxocobalamin Flashcards

1
Q

Hydroxocobalamin Drug Class

A

Antidote

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2
Q

Hydroxocobalamin Pharmacology

A

Form of vitamin B12 is an antidote for cyanide toxicity.

It binds with circulating and cellular cyanide to form cyanocobalamin, which is then excreted in the urine.

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3
Q

Hydroxocobalamin Metabolism

A

Excreted by kidneys

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4
Q

Hydroxocobalamin Indications

A

Suspected cyanide toxicity

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5
Q

Hydroxocobalamin Contraindications

A

KSAR

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6
Q

Hydroxocobalamin Precautions

A

Hypertension

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7
Q

Hydroxocobalamin Side effects

A
  • Anaphylaxis
  • Chromaturia
  • Erythema
  • Rash (acne like)
  • Hypertension
  • Nausea and/or vomiting
  • Pain at infusion site
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8
Q

Hydroxocobalamin Presentation

A

Vial (red powder), 2 x 2.5 g Hydroxocobalamin (Cyanokit®)

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9
Q

Hydroxocobalamin Onset (IV)

A

Immediate

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10
Q

Hydroxocobalamin Duration (IV)

A

Several days

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11
Q

Hydroxocobalamin Half-life (elimination)

A

26 – 31 hours

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12
Q

Hydroxocobalamin Schedule

A

N/A – TGA Special Access Scheme

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13
Q

Hydroxocobalamin Special notes

A

All hydroxocobalamin infusions are to be initiated using industry supplied stock. Hydroxocobalamin will not be procured by QAS

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14
Q

Hydroxocobalamin administration STEP 1 – RECONSTITUTE

A

Add 100 mL of sodium chloride 0.9%
to the 2.5 g hydroxocobalamin vial using the transfer spike (supplied)
Fill to the line with the vial in upright position.

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15
Q

Hydroxocobalamin administration STEP 2 – MIX

A

Rock or rotate the vial for 30 seconds to mix solution – DO NOT SHAKE.

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16
Q

Hydroxocobalamin administration STEP 3 – INFUSE VIAL

A

Use the vented IV infusion tubing (suppied) to hang and administer over 7.5 minutes.

17
Q

Hydroxocobalamin administration STEP 4 – REPEAT

A

REPEAT steps 1–3 for 2nd vial

18
Q

Hydroxocobalamin Adult dosages for cyanide toxicity

A

IV INF - 5 g over 15 minutes

Drug Therapy Protocols (Full) (23 decks)

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