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Drug Therapy Protocols (Full) > DTP Midazolam > Flashcards

DTP Midazolam Flashcards

1
Q

Pharmacology of midazolam

A
  1. Short acting CNS depressant
  2. Induces amnesia, anaesthesia, hypnosis and sedation.
  3. Enhances the action of inhibitory neurotransmitter GABA.
  4. Depressant effects at all levels of the CNS.
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2
Q

Metabolism of midazolam

A

By the liver, excreted by the kidneys

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3
Q

Indications of midazolam

A
  1. Seizures / convulsions

2. Sedation for : Acute behavioural disturbance (SAT score =>2)

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4
Q

Contraindications of midazolam

A

KSAR to midazolam

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5
Q

Precautions of midazolam

A
  1. Reduced dosages may be required in elderly pts, pts with chronic renal failure, CCF, or shock
  2. Can cause severe respiratory depression in pts with COPD
  3. Myasthenia Gravis
  4. Multiple sclerosis
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6
Q

Side effects of midazolam

A
  1. Hypotension

2. Respiratory depression particularly when associated with alcohol or narcotics

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7
Q

Presentation of midazolam

A

5mg/1ml

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8
Q

Onset of midazolam

A

IV/IN 1-3 mins

IM 5-15mins

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9
Q

Half-life of midazolam

A

2.5 hrs

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10
Q

Drug class midazolam

A

Short acting benzodiazepine

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11
Q

Schedule of midazolam

A

S4 restricted drugs

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12
Q

Duration of midazolam

A

variable

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13
Q

Midazolam Special Notes

A
  • Partial seizure activity in a patient who is unconscious or has ALOC should be treated as a generalised seizure.
  • If a patient has received midazolam or diazepam prior to arrival of paramedics, the amount administered is taken into account in the total dose administered.
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14
Q

Adult >70yo IM/IN Dose for seizure/convulsion

A

2.5mg
Rpt 2.5mg @ 10 mins
TMD 10mg

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15
Q

Adult

A

5 mg
Rpt 5mg @10 mins
TMD 20mg

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16
Q

Adult >70y/o IM dose of Midazolam for Acute behavioural disturbance (SAT score =>2)

A

up to 2.5mg
Rpt 1-5mg @10mins
TMD 15mg

17
Q

Adult 2)

A

up to 5mg
Rpt 5-10mg @10mins
TMD 25mg

18
Q

Adult >70 IV dose of Midazolam for Acute behavioural disturbance (SAT score =>2)

A

up to 2.5mg
@5mins 1-5mg
TMD 25mg

19
Q

Adult 2)

A

2.5-5mg
@5mins 2.5-5mg
TMD 25mg

20
Q

Paediatric IM/ IN doses of midazolam

A

200mcg/kg - SMD 5mg
repeat 1/2 initial (SMD 2.5mg)
@ 10mins
TMD 10mg

Drug Therapy Protocols (Full) (23 decks)

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