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Final NAPLEX > Dyslipidemia > Flashcards

Flashcards in Dyslipidemia Deck (6)
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1
Q

List eight drugs/drug classes that can increase LDL and TG

A
  1. protease inhibitors
  2. atypical antipsychotics
  3. steroids
  4. diuretics
  5. transplant drugs (cyclosporine, tacrolimus)
  6. oral estrogens and progestins
  7. retinoids
  8. tamoxifen, raloxifene
2
Q

List three drug classes that can increase LDL

A
  1. Fibric acids
  2. SGLT2 inhibitors
  3. Thiazolidinediones
3
Q

List six drugs that can increase TG only

A
  1. IV lipid emulsions
  2. Propofol
  3. Alcohol
  4. clevidipine
  5. bile acid sequestrants
  6. beta blockers
4
Q

List 7 statin equivalent doses from most potent to least potent (HINT: Pharmacists Rock At Saving Lives and Preventing Flu, PRAtSLPrFlu)

A
  1. Pitavastatin 2 mg
  2. Rosuvastatin 5 mg
  3. Atorvastatin 10 mg
  4. Simvastatin 20 mg
  5. Lovastatin 40 mg
  6. Pravastatin 40 mg
  7. Fluvastatin 80 mg
5
Q

List 12 strong CYP3A4 inhibitors that should be avoided with simvastatin and lovastatin

A
  1. itraconazole
  2. ketoconazole
  3. posaconazole
  4. voriconazole
  5. erythromycin
  6. clarithromycin
  7. HIV protease inhibitors
  8. cobicistat-containing (Tybost) [Genvoya, Stribild,Evotaz, Prezcobix]
  9. nefazodone
  10. cyclosporine
  11. danazol (with simvastatin)
  12. grapefruit juice
6
Q

List two specialty drugs for homozygous familiar hypercholesterolemia and their dosage forms

A
  1. Juxtapid (lomitapide, capsule)

2. Kynamro (mipomersen, prefilled SC syringe)