End of week questions

Question 1

Whats an agonist?

Answer 1

Ligand binds to active site of the receptor and activates the cell

Question 2

Whats a noncompetitive antagonist?

Answer 2

ligand binds to receptor at an allosteric site (non- active site), thus, changing the conformation of the active receptor site, making it impossible for the agonist to bind at its active site.

Question 3

Whats a prodrug?

Answer 3

precursor to active drug so that when the prodrug is metabolized by the liver, the drug is now active.

Question 4

What is the difference between efficacy and potency?

Answer 4

Efficacy: The maximum effect a drug will produce
Potency: How much drug is required to induce desired effect.

Question 5

Absorption changes in the elderly?

2

Answer 5

Increase gastric pH

Delayed gastric emptying

Question 6

What are the effect of these changes?

Answer 6

Decrease absorption rate of drugs with a lower pka

Drugs with a more basic pka will take longer to be absorbed

Question 7

GABA causes the release of what?

Answer 7

dopamine

causing euphoria

Question 8

endogenous opioids blocks the transmission of the action potential. What specifically does it block?

Answer 8

calcium channels