Endocannabanoids Flashcards Preview

Neuropsychopharmacology > Endocannabanoids > Flashcards

Flashcards in Endocannabanoids Deck (15)
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1
Q

What are some localisations for ECB?

A

Hippocampus
Basal Ganglia
Cerebellum

2
Q

What is the difference between CB1 and CB2?

A

CB1 has a much longer EC and IC terminal

3
Q

What does CB1 modulate conducation of?

A

Ca or K

4
Q

What is the action of CB1?

A

suppresses neuronal excitability, NT realease
NO production
Na Channel conduction

5
Q

On what kind of neurons can CB1 be found?

A

Gabaergic

6
Q

What are the two known stimulators of CB1?

A

Anandamide

2-AG

7
Q

What breaks down Anandamide

A

FAAH

8
Q

What breaks down 2-AG

A

MGL

9
Q

What is a DSI?

A

depolarisation induced suppression of inhibition

10
Q

What is a DSE?

A

depolarisation induce suppression of excitation

11
Q

What is retrograde transmission?

A

endocannabanoid released back to the presynaptic receptor to inhibit Ca influx and the release of GABA

12
Q

What are the chronic effects of ECB use?

A
respiratory effects
cardiovasular arrhythmia
immune comprimised
reproduction compromised
amotivational
impaired thinking and reasoning
increased tolerance and addiction
13
Q

What are the acute effects?

A

impaired STM and learning
anxiety, fear
analgesia
increased apetite

14
Q

What happens to food intake and body weight gain?

A

reduced in rats when antagonised

15
Q

What helps synthesis 2-AG?

A

DAG