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PH 152 > Enteric Viruses > Flashcards

Enteric Viruses Flashcards

1
Q

Rotavirus is a Reovirus. What does REO mean?

A

REOVirus : - Respiratory Enteric Orphan Virus

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2
Q

genome of Reovirus

A

double stranded RNA

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3
Q

False about Reovirus virion
A.Two concentric helical capsid with capsomeres
B. contains several enzymes for transcription
and capping of viral RNA
C. both

A

A

icosahedral dapat

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4
Q

False about Reovirus
A. no envelope
B. replication is at nucleus & virions not completely coated
C. stable to heat, 3-9pH & lipid solvents
D. inactivated by 95% ethanol, phenol, chlorine

A

B

cytoplasm dapat

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5
Q 
Reovirus is stable in all except
A)heat
B)95% ethanol
C)3-9 pH 
D)lipid solvents
A

B

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6
Q

Rotavirus group __ : primary human pathogens

A, B, C, D

A

A

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7
Q

For Rotavirus: outer capsid proteins used for serotyping

A

VP4, VP7

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8
Q

protein in intermediate capsid (rota virus)

A

VP6

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9
Q

protein in inner capsid (rotavirus)

A

VP2

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10
Q

Mature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

A

A

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11
Q

Immature form is __
A. triple-shelled capsid
B. double-shelled capsid
C. single-shelled capsid

A

B

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12
Q

viral protein in Rotavirus for binding & defining P serotype

A

VP4

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13
Q

viral protein in Rotavirus for defining G serotype

A

VP7

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14
Q

Rotavirus attaches via VP4 to what host cell receptor?

A

sialic acid

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15
Q

in rotavirus

what cleaves VP4 to VP8 and VP5?

A

Trypsin enzyme

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16
Q

reduction in __ of outercapsid leads to removal of VP7. releasing double shelled virus

A

Ca

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17
Q

What do VP1 and VP3 facilitate? for rotavirus
A. significant parts of central dogma
B. attachment
C. virus assembly

A

A

transcription, translation, protein syn

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18
Q

Rotavirus lyses the cell. T or F?

A

T

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19
Q

Most common G serotype all over the world for rotavirus

A

G1

20
Q

Most common G serotype in country for rotavirus

A

G3

21
Q

viral enterotoxin c/o rotavirus that induces diarrhea

A

non-structural protein 4

22
Q

which parts of GIT are most affected by rotavirus?

A

proximal duodenum to proximal jejunum

23
Q

which is false?
A. rotavirus only takes small inoculum to develop disease
B. rotavirus affects gastric and colonic mucosa
C. rotavirus may also cause lack of sugar degradation
D. more common during cold months

A

B

24
Q

clinical triad of rotavirus

A

fever, vomiting, diarrhea

25
Q

rotavirus has respiratory symptoms, t or f?

A

t

REOvirus!! symptoms: cough, coryza

26
Q

most sensitive method of diagnosis for rotavirus

A

PCR

27
Q

Rotavirus can be cultured in media with __

A

trypsin

28
Q

vaccine for rotavirus is
A.combination
B.pure polysaccharide
C.live attenuated

A

C

given orally, too :)

29
Q

official name of norovirus

A

norwalk-like viruses

30
Q

family of norovirus

A

Caliciviridae

31
Q 
false about norovirus
A. 6 =number of genogroups @ norovirus
B. genome is (+)ssRNA
C. virion is icosahedral
D. enveloped virus
A

D

naked say

32
Q

defining char of norovirus surface

A

cup like depression

33
Q

non-structural protein from RNA involved in RNA transcription

A

VPg

34
Q

norovirus affects what part of GIT?

A

Proximal duodenum

proximal jejunum

35
Q

enumerate what is/are malabsorbed due to norovirus

A

fat, lactose and D-xylose

36
Q

most common clinical manifestation of norovirus

A

stomach flu

37
Q

Once you have been infected with Norovirus, you are forever immune. true or false?

A

false;no lifelong immunity

38
Q

most widely used technique to detect Caliciviruses

A

PCR

39
Q

Vaccine is available for people who wish to not get Norovirus. T or F?

A

F

40
Q

Genus of Astrovirus

A

Mamastovirus

41
Q 
false about Astrovirus
A. icosahedral virion
B. single strand negative sense RNA
C. no envelope
D. stable in acid and resistant to heat
A

B

positive!!

42
Q

most important capsid proteins of astrovirus

A

VP26 and VP29

43
Q

symptomatic duration for astrovirus

A

3-4 days

44
Q

most useful way of diagnosing astrovirus

A

electron microscopy

45
Q

A. orofecal transmission
B. highest infection rates in summer months
C. low infective dose
D. symptomatic treatment

False about astrovirus

A

B

rainy dapat

46
Q

body’s mechanism of immunity vs rotavirus

A

local intestinal IgA

PH 152 (47 decks)

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