Environmental carcinogenesis Flashcards Preview

Cancer Risk Assessment > Environmental carcinogenesis > Flashcards

Flashcards in Environmental carcinogenesis Deck (20)
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1
Q

NHEJ

A

Non-homologous end joining

2
Q

HRR

A

homologous recombination repair

3
Q

BER

A

Base excision repair

4
Q

NER

A

Nucleotide excision repair

5
Q

MMR

A

mismatch repair

6
Q

HNPCC

A

Human Non-polyposis Colon Cancer

causes colon cancer

7
Q

HNPCC type of damage

A

mismatch repair

8
Q

Ataxia telangiectasia

A

lymphomas and leukemias

9
Q

Bloom syndrome

A

leukemias, lymphomas, carcinomas

10
Q

Cockayne’s syndrome

A

no known cancer

11
Q

Trichothiodystrophy

A

no known cancer

12
Q

Werner syndrome

A

thyroid cancer, melanoma, sarcoma, osteosarcoma

13
Q

Xeroderma pigmentosum

A

skin cancer
sensitive to UV radiation
7 nucleotide excsion repair genes

14
Q

gorlin syndrome

A

BCC, meduloblastoma
sensitive to IR
PTCH gene

15
Q

pyrimidine dimer formed by

A

254 nm UV

16
Q

pyrimidine dimer destroyed by

A

> 320 nm UV

17
Q

% cancer that are melanoma

A

5%

18
Q

PAH

A

polycyclic aromatic hydrocarbons

19
Q

Discovered PAH

A

Percival Pott

20
Q

PAH in chimney sweeps

A

scrotal cancer