Flashcards in Final Exam Review - Khan Deck (120)
Acute myeloid leukemia affects what age group?
What causes acute myeloid leukemia?
clonal proliferation and myeloblasts in the marrow
What is the most common chromosomal abnormality?
Acute myeloid leukemia
Acute myeloid leukemia with translocations between which chromosomes?
chromo 8 and 21 or chromos 15 and 17
What may be present in the cyoplasm in Acute myeloid leukemia?
eosinophilic, slender cytoplasmic inclusions called Auer rods
Chronic myelogenous leukemia (CML) peaks at what age?
30s and 40s, slight male predominance
90 % of patients with Chronic myelogenous leukemia (CML) have what chromosome?
(Philadelphia) Ph chromosome- (translocation of chromosome 9 to 22 BCR/ABL gene)
A patient presents with fatigue, anorexia, weight loss, and vague abdominal discromfort caused by hepato splenomegaly. What is the pathology?
Chronic myeloid leukemia (CML)
What is present in bone marrow with Chronic myeloid leukemia (CML)?
band cells (unsegmented nuclie) and meta myelocytes
What is often a symptom of splenic infarction?
acute left upper quadrant pain
Chronic lymphocytic leukemia (CLL) is caused by what?
malignant proliferation of small mature-appearing lymphoid cells
- pro lymphocytes in the blood
Which type of Chronic lymphocytic leukemia (CLL) has an average survival of 5 years?
CLL is that is positive for marker ZAP-70
CLL negative for ZAP-70 has a survival of more than how many years?
What can develop as Chronic lymphocytic leukemia (CLL) advances?
- severe anemia
Chronic lymphocytic leukemia (CLL) results in what?
swollen lymph nodes
Chronic lymphocytic leukemia (CLL) may transform into what syndrome?
Transformation of Chronic lymphocytic leukemia (CLL) into Richter's syndrome is characterized by what?
- worsening cytopenias
- increasing splenomegaly
- progressive increase in the number of prolymorphocytes in the peripheral blood
What is the most common type of Chronic lymphocytic leukemia (CLL) transformation?
transformation to prolymorphocytic leukemia (15-30%)
Transformation in a CLL patient includes what symptoms?
- fever, weight loss and muscle atrophy, and enlarged lymph nodes
8 % of all CLL patients will have elevated levels of what?
serum lactate dehydrogenase (LDH)
A clonal B-cell neoplasm composed of small to medium sized lymphocytes with abundant pale cytoplasm describes what?
Hairy cell leukemia
- hair-like cytopasmic protrusions
Hairy cell leukemia involves what body areas?
bone marrow and peripheral blood
What is the male to female ratio for Hairy cell leukemia?
What are lymphomas?
malignant proliferations of lymphocytes
- mostly affects lymph nodes but can attach any tissue/organ
When lymphoma involves the peripheral blood or bone marrow it is said to be what?
Lymphomas are caused by translocations between what chromosomes?
9 and 22
B-cell, T-cell, and NK cell lymphomas are cateorized as what?
immature - from precursor cells; lymphoblasts
- mature are form mature effector cells
What are the types of low grade lymphomas?
- small lymphocytic lymphoma
- MALT lymphoma
- Follicular lymphoma
- mycosis fungoides
Low-grade lymphomas occur in what population?
- older patients
- INDOLENT (incurable)