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1

Acute myeloid leukemia affects what age group?

15-39 years

2

What causes acute myeloid leukemia?

clonal proliferation and myeloblasts in the marrow

3

What is the most common chromosomal abnormality?

Acute myeloid leukemia

4

Acute myeloid leukemia with translocations between which chromosomes?

chromo 8 and 21 or chromos 15 and 17

5

What may be present in the cyoplasm in Acute myeloid leukemia?

eosinophilic, slender cytoplasmic inclusions called Auer rods

6

Chronic myelogenous leukemia (CML) peaks at what age?

30s and 40s, slight male predominance

7

90 % of patients with Chronic myelogenous leukemia (CML) have what chromosome?

(Philadelphia) Ph chromosome- (translocation of chromosome 9 to 22 BCR/ABL gene)

8

A patient presents with fatigue, anorexia, weight loss, and vague abdominal discromfort caused by hepato splenomegaly. What is the pathology?

Chronic myeloid leukemia (CML)

9

What is present in bone marrow with Chronic myeloid leukemia (CML)?

band cells (unsegmented nuclie) and meta myelocytes

10

What is often a symptom of splenic infarction?

acute left upper quadrant pain

11

Chronic lymphocytic leukemia (CLL) is caused by what?

malignant proliferation of small mature-appearing lymphoid cells
- pro lymphocytes in the blood

12

Which type of Chronic lymphocytic leukemia (CLL) has an average survival of 5 years?

CLL is that is positive for marker ZAP-70

13

CLL negative for ZAP-70 has a survival of more than how many years?

25 years

14

What can develop as Chronic lymphocytic leukemia (CLL) advances?

- severe anemia
- thombo-cytopenia
- neutropenia

15

Chronic lymphocytic leukemia (CLL) results in what?

swollen lymph nodes

16

Chronic lymphocytic leukemia (CLL) may transform into what syndrome?

Richter's syndrome

17

Transformation of Chronic lymphocytic leukemia (CLL) into Richter's syndrome is characterized by what?

- worsening cytopenias
- increasing splenomegaly
- progressive increase in the number of prolymorphocytes in the peripheral blood

18

What is the most common type of Chronic lymphocytic leukemia (CLL) transformation?

transformation to prolymorphocytic leukemia (15-30%)

19

Transformation in a CLL patient includes what symptoms?

- fever, weight loss and muscle atrophy, and enlarged lymph nodes

20

8 % of all CLL patients will have elevated levels of what?

serum lactate dehydrogenase (LDH)

21

A clonal B-cell neoplasm composed of small to medium sized lymphocytes with abundant pale cytoplasm describes what?

Hairy cell leukemia
- hair-like cytopasmic protrusions

22

Hairy cell leukemia involves what body areas?

bone marrow and peripheral blood

23

What is the male to female ratio for Hairy cell leukemia?

5:1

24

What are lymphomas?

malignant proliferations of lymphocytes
- mostly affects lymph nodes but can attach any tissue/organ

25

When lymphoma involves the peripheral blood or bone marrow it is said to be what?

leukemic

26

Lymphomas are caused by translocations between what chromosomes?

9 and 22

27

B-cell, T-cell, and NK cell lymphomas are cateorized as what?

immature - from precursor cells; lymphoblasts
- mature are form mature effector cells

28

What are the types of low grade lymphomas?

- small lymphocytic lymphoma
- MALT lymphoma
- Follicular lymphoma
- mycosis fungoides

29

Low-grade lymphomas occur in what population?

- older patients
- INDOLENT (incurable)

30

Low-grade lymphomas have what cell type?

- small, non-destructive, mature cells