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Flashcards in final lecture 5 Deck (20)
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1
Q

osteoporosis contributing factors

A

genetics, diet, lifestyle, hormones, diseases, meds

2
Q

bone mineral density is commonly expressed as

A

T score which compares to average

3
Q

normal BMD

A

T score between +1 & -1

4
Q

osterpenia

A

T score between -1 & -2.5

5
Q

osteoporosis

A

t score <2.5

6
Q

OP is more common in

A

women

7
Q

heterogenous disease divided into 3 categories

A

postmenopausal, age-related, secondary

8
Q

most common secondary cause

A

glucocorticoid therapy

9
Q

bone remodeling

A

breakdown & renewal of bone; requires 3-4 months to complete

10
Q

osteoclasts

A

degrade bone
acid pH dissolves hydroxyapatite crystals
enzymes degrade the collagen & other extracellular fibers

11
Q

osteoblasts

A

build bone

secrete OSP->inhibits osteoclasts

12
Q

postmenopausal OP

A

due to increased bone resorption due to estrogen deficiency

13
Q

secondary causes of Op

A

glucocorticoids, heparin, TH, anticonvulsants, disease

14
Q

kyphosis

A

exaggerated posterior curvature of the thoracic spin(round back)
associate w/ respiratory & GI complcations

15
Q

lordosis

A

exaggerated anterior curvature of the lumbar & cervical regions of the spine

16
Q

most common fractures

A

vertebral

17
Q

worst fractures

A

hip

18
Q

two mechanisms that take Ca up across intestine

A

vitamin D dependent active transport & facilitated diffusion

19
Q

reabsorption of Ca regulated by

A

PTH

raises plasma Ca

20
Q

osteoclasts ___ a PTH receptor

A

do not have