final lecture 7 Flashcards
hepatic enzyme that requires vitamin K
gamma-glutamyl carboxylae
____ reduces vitamin K to its active form
VKOR
chief clinical manifestation of vitamin K deficiency
increased bleeding
warfarin is a synthetic derivative of
dicoumarol
warfarin is a
racemic mixture
which enatiomer is the most potent in warfarin
S!
warfarin & protein binding
almost completely bound to proteins
warfarin CYP pathways
3A4 & 2C9
polymorphisms in ___ account for most of the variability of warfarin
2C9
INR is a
mathematical correction of PT
allows for comparison of results between lab and standardized reports
large loading dose of warfarin causes
abrupt fall in factor VII and protien C but do not speed up IX, X or II
warfarin antidote
vitamin k
reduce warfarin effects
cholestyramine, nephrotic syndrom, chronic alcohol, rifampin, vitamin K, prego
increase warfarin effects
ABX, vit K deficiency, impaired hepatic function, apsirin, age
warfarin is not suitable for
acute intervention