final lecture 9

Question 1

HAT

Answer 1

plt sequestration

Question 2

HIT

Answer 2

IgG antibodies

Question 3

diagnosis of HIT

Answer 3

4T score
thrombocytopenia
timing
thrombosis
other

Question 4

agratroban dose

Answer 4

DTI
alt. anticoag in HIT
2mcg/kg/min
goal aPPTL 1.5-3

Question 5

lepirudin

Answer 5

DTI
alt. anticoag in HIT
aPTT 4 hours after initiation: 1.5-2

Question 6

bivalirudin

Answer 6

DTI

alt. anticoag in HIT

Question 7

drug induced thrombocytopenia

Answer 7

quinine, quinidine, vancomycin, heparin, pip/tazo

Question 8

drug-induced aplastic anemia

Answer 8

2 of theses:

WBC<30,000

Question 9

severe aplastic anemia

Answer 9

2 of these:
ANC<20,000
anemia

Question 10

drug induced aplastic anemia causes

Answer 10

chloramphenicol, felbamate, antineoplastic agents

Question 11

drug induced agranulocytosis causes

Answer 11

beta-lactam ABX, valprioc acid, clozapine

Question 12

agranulocytosis management

Answer 12

GF support for chemo induced

Question 13

drug induced hemolytic anemia diagnosis

Answer 13

coombs test

Question 14

hemolytic anemia drug causes

Answer 14

beta-lactam ABX, methyldopa

Question 15

drug induced oxidative hemolytic anemia most common cause

Answer 15

G6PD deficiency

drugs- dapsone, sulamethoxazole

Question 16

drug induced megaloblastic anemia causes

Answer 16

metformin, methotrexate, phenytoin & phenobarbital

Question 17

megaloblastic anemia treatment

Answer 17

folate & vit B12