Initial effect of inhaling CO
Headache
Chronic use of steroidal anti-inflamatory meds will cause what 3 effects?
Ulcers
Hyperglycemia
Cataracts
What does NO do?
Oxidizes Hb to form methemoglobin
Aspirin should not be used to manage what?
Gouty Arthritis
Chronic steroidal anti-inflammatory use can cause GI ulcers because of inhibition of which enzyme?
Phospholipase A2
Effects of CO inhalation
- reduces Hb available to transport O2
- mis-Dx as flu
- can cause fetal damage
Air pollutants wcause which symptom?
Pulmonary edema
Whats happens with dermal contact with a strong acid (HCl)
Superficial damage with eschar formation
Hypertensive crisis is a serious adverse interaction involving which substances?
Monoamine Oxidase Inhibitors
Delayed-onset pulmonary toxicity is characteristic of which chemical exposure?
Inhalation of irritant gas with low water solubility
Methemoglobinemia is characterized by what?
Caused by exposure to oxidizing chemicals
Person using corticosteroids for OA over a chronic duration will have hyperglycemia due to what reason?
Stimulation of GNG
Exposure to organophosphate insecticide (ACh transferase inhibitor) will cause what effect?
increased exocrine secretions
CO has the greatest binding affinity for which Hb?
Fetal Hb
Mad Hatter’s Dz is a consequence of chronic exposure to what?
Mercury
Risk for Parkinson’s and angina is increased upon exposure to what?
CO
Daily use of low doses of aspirin is prescribed to pts to prevent intra-vascular clotting after CV surgery. What is the rationale?
Inhibits thromboxane synthetase
Cheyne-Stokes resiration is caused by fluctuations in PCO2 level. This is a characteristic effect of what?
Narcotic analgesic ovedose
Chronic use of what therapeutic agent is most liley to increase risk for fx and osteoporosis
Proton pump inhibitor
NO must be combined w/ adequate O2 when used to perform denatl procedures in order to prevent what?
Methemoglobinemia
CO does NOT cause which effect?
Coughing
Highly soluble irritant gases pose the highest risk for adverse effects in pts. with what condition?
Asthma
The best confirmation of CO poising is what?
Carboxymethemoglobin blood levels
What toxic chemical has a sweet taste?
Lead acetate
What category of chemicals will cause liquefactive necrosis upon contact with living tissues?
Strong bases
Excessive consumption of what food item will increase risk for mercury poisoning?
Bigeye tuna
What poison causes psychosis?
mercury
non-steroida anti-inflammatory meds. provide palliative relief by inhibiting what enzyme?
Cyclo-oxygenase
Acute overdose w/ aspiring can cause hyperthermia. Why does this occur?
Aspirin uncouples Ox-Phos
Even low dose use of aspirin on chronic basis can increas risk for GI ulcers b/c why?
Aspirin inhibits Cox 1 in teh gastric mucosa
Which is Not an anti-inflammatory steroid?
Testosterone
*Cortisol, prednisone, and Dexamethasone are inflammatory
Acute overdose w/ what produces centrilobular hepatic necrosis?
tylenol
Associated with Reyes syndrome
Aspirin
Causes Hyperglycemia through Glycogenolysis
Epinephrine
Stimulate GNG
Prednisone
Used to manage viral fevers in children
Tylenol
Causes Hypoglycemic coma
Insulin
Can cause toxic effects during rapid weight loss
Lipophilic chemicals
Can increase bio-inactivation by liver enzymes
Smoking
Can increase toxicity due to therapeutic doses of any chemical
Inadequate H2O intake/ dehydration
Overdoses can cause cardiac palpitations
Synthroid
Therapeutic use can cause hyperglycemia
Hydrocortisone