Finals week RA drugs

Question 1

What is the action of Methrotrexate?

Answer 1

Blocks dihyrdofolate reductase (anti-folate)

Question 2

What is the mechanism of hydroxychloroquine?

Answer 2

Prevents acidification of macrophage cytosol by blocking TLR-9

Question 3

What is the mechanism of Leflunomide

Answer 3

Inhibits pyrimidine synthesis (blocks ororate pathway)

Question 4

What is the mechanism of sulfasalazine

Answer 4

Pro-drug that gets converted into sulfapyridine (free radical scavenger), and 5 amino-salicylic acid (COX antagonist)

Question 5

What is the mechanism of gold?

Answer 5

Suppresses phagocytosis by macrophages, suppresses antigen presentation and T cells

Question 6

What is the mechanism of Azathioprine?

Answer 6

Blocks DNA synthesis primarily in T cells

Question 7

What is the mechanism of cyclosporin?

Answer 7

Calcineurin inhibitor to inhibit T cell activation

Question 8

What is the mechanism of Etanercept and Inflixumab

Answer 8

Blocks DNA TNF action

Question 9

What is the mechanism of anakinra?

Answer 9

IL-1 receptor antagonist

Question 10

What is the mechanism of abatacept?

Answer 10

Blocks T cell activation by antigen presenting cell (Binds CD80)

Question 11

What is the mechanism of Ritixumab

Answer 11

Blocks B cell activation (Binds CD20)

Question 12

What are the 4 options for RA treatment?

Answer 12

NSAIDs, Corticosteroids, Non-biological DMARDs, Biological DMARDs