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Endocrine Pharmacology > Fitzy Specifics > Flashcards

Flashcards in Fitzy Specifics Deck (36)
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1
Q

Goserelin and Leuprolide MOA and use?

A

GnRH agonist for lowering T and Estrogen

2
Q

Major SE of GnRH agonists?

A

Flare

  • Bone Pain
  • Prostatic Hypertrophy – Urethral obstruction
  • FATAL spinal cord compressiomn
3
Q

Delayed SE of GnRH agonists?

A

Low T/E
Impotence
Osteoporosis
Hot Flashes (E)

4
Q

Degralix MOA and use?

A

GnRH antagonist for Prostate Cancer

5
Q

Problem with Degralix duration?

A

Short duration with cost and compliance issues

6
Q

Degralix SE?

A

HISTAMINE (Rash, anaphylaxis, hypotnesion)

7
Q

Dutasteride and Finasteride MOA?

A

5-a-reductase inhibitors

8
Q

Major Toxicity of 5-a-reductase inhibitors?

A

TERATOGENIC even if wife handles the pill

9
Q

Abraterone Acetate MOA and use?

A

CYP17 inhibitor for Castration-resistant prostate cancer

10
Q

Aminoglutethimide MOA?

A

NON-STEROIDAL
Inhibits Aromatase
Inhibits conversion of cholesterol –> Pregnenolone

11
Q

Aminoglutethimide SE?

A
Acute = Nausea, fever, fatigue
Chronic = Adrenal insufficiency, Myelosuppresion
12
Q

3rd gen aromatase inhibitors?

A

Exematide (Steroidal)
Anastrozole (Non-steroidal)
Letrozole

13
Q

1st line TX for ER+ breast cancer?

A

Aromatase inhibitors

14
Q

SE of aromatase inhibitors?

Good effect?

A

Acute = headache, nausea
Polyarthralgia, osteoporosis

Lowers LDL and raises HDL

15
Q

Aromatase main effect in Pre-menopausal women?

A

T –> Estradiol in OVARIES

16
Q

Aromatase main effect in Post=menopausal women?

A

Androstene –> Estrone in ADIPOSE

17
Q

Bicalutamide and Flutamide MOA?

A

Inhibit Androgen receptor translocation to cell surface

18
Q

Use of biclutamide/flutamide?

A

Prevent flare during GnRH analog administration

19
Q

Delayed tox of biclutamide/flutamide?

A

LIVER TOX
gynecomastia
Decreased T

20
Q

Hydroxyprogesterone
Medroxyprogesterone
Megestrol
MOA?

A

Progesterone R antagonists

21
Q

Uses of Progesterone R antagonists?

A

2nd line for ER+ breast cancer

Endometrial cancer

22
Q

SERMs (3)?

A

Tamoxifen
Toremifine
Raloxifene

23
Q

SERD?

A

Fulvistrant

24
Q

SERM agonist in bone and uterus?

A

Tamoxifen

25
Q

SERM agonist in uterus, no bone effect?

A

Toremifene

26
Q

SERM agonist in bone, antagonist in uterus?

A

Raloxifene

27
Q

SERD antagonist in uterus and bone?

A

Raloxifene

28
Q

Which SERM increases risk of endometrial cancer?

A

Tamoxifen

29
Q

Which SERM is used as a 2nd line ER+ breast cancer tx?

A

Tamoxifen

30
Q

Which SERM is used for prevention if DCIS?

A

Tamoxifen

31
Q

Which estrogen modulators are administered orall?

A

Tamoxifen
Toremifene
Raloxifene

32
Q

Which estrogen modulator is administered IM injection?

A

Fulvestrant

33
Q

SE of all estrogen modulators?

A
Hot flashes
nausea
vomiting
dysmennorhea
Vaginal Bleed
Dermatitis
34
Q

Specific fulvestrant SE?

A

GI symptoms
Headache
Back Pain
Pharyngitis

35
Q

Peak conc of SERMs?

A

4-7 hrs (Faster)

36
Q

PEak conc of SERD?

A

7 days (Slower)