Flucloxacillin Flashcards Preview

Pharmacology - Antibiotics and Infection > Flucloxacillin > Flashcards

Flashcards in Flucloxacillin Deck (8)
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1
Q

What are common indications for flucloxacillin use?

A
  • Skin/soft tissue infection
  • Osteomyelitis
  • Septic arthritis
  • Endocarditis
  • Other infections
2
Q

Why is flucloxacillin effective against B-lactamase producing bacteria?

A

Acyl side chain protects the B-lactam ring from B-lactamases

3
Q

How does MRSA resist the action of flucloxacillin?

A

Reduces penicillin binding affinity

4
Q

What are important side effects of flucloxacillin?

A
  • GI upset
  • Allergy
  • Liver toxicity - cholestasis, hepatitis
  • CNS toxicity
5
Q

When is flucloxacillin contraindicated for use?

A

Prior Fluclox-related hepatotoxicity

6
Q

What is the dose regimen used for administering flucloxacillin in an adult using oral tablets?

A

250-500 mg 4 times per day

7
Q

Why does flucloxacillin need to be administered 6-hrly?

A

Short plasma half-life of 45-60 minutes - excreted renally

8
Q

How might you monitor efficacy of flucloxacillin?

A
  • Symptoms/signs
  • Blood markers