Friday Heme 4.5 Flashcards Preview

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Flashcards in Friday Heme 4.5 Deck (11)
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1
Q

pt w aplastic anemia has low numbers of __
__ is inc by kdney
iron/haptoglobin should be __
white cells in aspirate should appear morphologically __

__ anemia presents w short stature and absent thumbs
inc risk of __ malig

Parvo infection only produces aplastic crisis in pt w preexisting __ dz

A

all cell lines
EPO
normal

normal

hematologic

2
Q

cells undergoing DNA synthesis must be in the __ phase of cell cycle
normally inhibited by __ in hypophosphorylated form

if cell is stimulated by GF, activation of cyclin / and CDK4/6 phosphroylates Rb
releases __ to allow cell prog
if Rb is hypophos, it is bound to __ acting as break

p27 is cell cycle inhibitor
inhibits __ at high levels

A

S
Rb

D, E
E2F
E2f

CDK kinases

3
Q

in bruise, Hb containing E__ escape to tissue
gives bruse the __ color
destruction releases heme, and is degraded by HO into biliverdin
this produces the __ color

biliverdin eductae then degrades it to __ which is transported to the liver
may see __ color

A
enterocytes
blue
heme oxygenase
green
bilirbin
yellow
4
Q

ALAS is inhibited by G/H
PBG Deaminase pt are asx until induction of __

__ carcinomas arise from transitional epithelium of bladder
presents w painless __
usually resemble normal __, called urotheial ca
SCC/adeno are __

can grow as papillary or __ mass
__ indicates confined to epithelium
further penetration has __ prognosis

A

glucose/hemin
ALAS

bladder
hematuria
epithelium
rare

sessile
CIS
poor

5
Q

pt w eczema, recurrent infections and thrombocytopenia has __ dx
inheritance is __
combined _/__ cell disorder
at risk for __ org infections
T cell defect leads to susceptibility for P/H infections
pt is symptomatic after losing __/__ from mother at 6m
tx w HLA matched ___

C__ syndrome presents w oculocutaneous albinism, peripheral Neuro, and immunodef of phagosome/lysosome fusion

A
Wiscott Aldrich
X linked
B cell, T cell
encapsulated
pneumocystis, herpes
IgG, IgA
bone marrow transplant

chediak higashi

6
Q

tx of HER2 neu occurs w monoclonal ab __
tx ER pos BC w estrogen Receptor modulator T (premen)
or aromatase inhibs A/L (post men)

use RANKL antibody D to inhibit OC

vWF deficiency has __ pattern of inheritance

A

trastuzumab
tamoxifen
anastrozole, letrozole

denosumab

AD

7
Q

pt w sx of anemia, but normal WBC/platelets and marrow precursors has __ aplasia
caused by severe hypoplasia of __ elements w normal granulo/thrombopoeisis

IgG/CD8 T cells inhibits __ precursors
assc w T/L
w thymoma, removal can __

can also be due to __ infection, as it attacks p__
look for infection w presence of anti-B19 __ in serum

A

pure red cell aplasia
marrow

RBC
thymoma, lymphocytic leukemia
cure

parvo
promyeloblasts
IgM

8
Q

VEGF and __ can stimulate angiogenesis
VEGF inc endothelial cell __ and prolifration

FGF is important in endothelial __ and Migration and differentiation
may stimulate __
important in H__ and wound repair

IL1 and INFG can stimulate macrophages, which can release __

Laminin in basement membrane can __ sprouting blood vessels

A

FGF
motility

proliferation
angioblasts
hematopoeisis

VEGF

inhibit

9
Q

HbA1c is elevated w high __ or long __ of red cells to glucose

HbA2 is upregulated in __ to compensate for dec beta chains

this can falsely dec __ in pt

HUS causes thrombocytopenia by damaging __, resulting in platelet adherence
microthrombi then __ platelets
damage to glomerular __ cells results in AKI

platelet count is __
all other clotting studies are __

A

gucose, exposure

B thalassemia

HbA1c

endothelium
shear
endothelial cells

low
normal

10
Q

osteomyelitis in Sickle cell pt is S, then S and E

vinca alkaloids disrupt __ mcrotubules responsible for transporting organelles/cell products bw neuron cell body and axon terminal

phase G2 of cell cycle, DNA is checked for __
if cannot be corrected, apoptosis will result unless __ mutation occurs
drugs like B/D act here

__ is cell cycle nonspecific

A

salmonella, staph, e coli

neuronal

mutations
loss of fxn
bleomycin, doxorubicin

cyclophosphamide

11
Q

AI hemolytic anemia is not __
coombs test is ___
have propensity for __ AI cx

pt w excessive __ can have excessive bleeding

labs wil be __ except for inc __
tx w __

A

inherited
positive
other

uremia

normal, bleeding time
dialysis