GABA receptor pharmacology Flashcards Preview

Neuropsychopharmacology > GABA receptor pharmacology > Flashcards

Flashcards in GABA receptor pharmacology Deck (12)
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1
Q

What is the GABA transporter?

A

GAT 1-3

2
Q

What is the VGAT?

A

vesicular GABA Amino acid transporter

3
Q

What are the effects of drugs acting on GABA?

A

anxiolytic, sedative, analgesic, amnestic, hypnotic, anaesthetic, anticonvulsant

4
Q

What are PAMs of GABA?

A

diazepam

5
Q

What is an Antagonist of GABA?

A

flumazenil

6
Q

WHat is a NAM of GABA?

A

b-carbolin

7
Q

What effects are caused by a1?

A

sedative, not addictive

8
Q

What effects are caused by a2?

A

anxiolytic, analgesic, develops tolerance

9
Q

What effects are caused by a5?

A

KO causes improved performance

10
Q

Where are a5 found?

A

hippocampal CA1 neurons - tonic current

11
Q

What effects are lost with a5 KO?

A

sedative, general anaesthetic and cognitive impairment

12
Q

How can you assay for recombinant GABAaRs?

A

displacement of 3H flunitrazepam

Whole cell clamp