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Flashcards in Gene Discovery Deck (8)
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1
Q

Polytene chromosomes

A
2
Q

RFLPs

A

Restriction fragment length polymorphisms

3
Q

Microsatelllites

A

DNA repeats that vary in length

4
Q

LOD score

A
  1. Calculate the likelihood of observing the genotype data if there is linkage to the trait
  2. Calculate the likelihood of observing the genotype data if there is no linkage to the trait
  3. LOD (log of the odds) score = log of the ratio of these two likelihoods
5
Q

Bonferroni correction

A
6
Q

For GWAS, P values should be ____ or lower to be considered genome-wide significant

A

For GWAS, P values should be ~ 5x10-8 or lower to be considered genome-wide significant

7
Q

For polygenic disease, nearly all OR are ____.

A

For polygenic disease, nearly all OR are < 3 and > 0.33

8
Q

Allelic odds ratio

A