General Antineoplastics- Fitz Flashcards Preview

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Flashcards in General Antineoplastics- Fitz Deck (11):
1

What are cell cycle specific drugs good at killing?

quickly proliferating cells

2

When would you use a cell cycle non-specific drug?

Slowly dividing tumors
Kills both proliferating and non-proliferating cells
Dosage matters more than scheduling

3

What is the cell kill hypothesis?

Actions of CCS drugs follow first order kinetics, a given dose kills a constant PROPORTION of a tumor cell population (NOT NUMBER)

4

What are some characteristics of the cancer that affect outcome?

Growth fraction (% of cells not in G0)
Double times
Type and stages
Resistances

5

What are some characteristics of the patients that can affect outcome?

Overall health
Bone marrow capacity
Liver/kidney function
Age
Compliance

6

What is primary resistance?

Some inherent characteristic of the cancer cells that prevents the drugs from working

Ex: Lack of expression of RFC receptor

7

What is acquired resistance?

Occurs when cancer cells become resistance during treatment

8

What is multiple resistance?

When tumor cells become cross-resistant to a wide rang of chemically dissimilar agents after exposure to a single drug

9

What are some things that can cause resistance?

Poor drug distribution
Sanctuary sites (esp brain)
Tumor cells not in cycle
Heterogeneity of tumor cells leading to clonal selection

10

Increased expression of MDR-1 gene would lead to what?

Increased level of P-glycoprotein

11

Critical points concerning the cell kill hypothesis

Early treatment is helpful

Treatment must continue past the time when cancer cells can't be detected using conventional techniques

Appropriate scheduling of treatment courses and care to achieve sufficient log-kill