Flashcards in General Antineoplastics- Fitz Deck (11):
What are cell cycle specific drugs good at killing?
quickly proliferating cells
When would you use a cell cycle non-specific drug?
Slowly dividing tumors
Kills both proliferating and non-proliferating cells
Dosage matters more than scheduling
What is the cell kill hypothesis?
Actions of CCS drugs follow first order kinetics, a given dose kills a constant PROPORTION of a tumor cell population (NOT NUMBER)
What are some characteristics of the cancer that affect outcome?
Growth fraction (% of cells not in G0)
Type and stages
What are some characteristics of the patients that can affect outcome?
Bone marrow capacity
What is primary resistance?
Some inherent characteristic of the cancer cells that prevents the drugs from working
Ex: Lack of expression of RFC receptor
What is acquired resistance?
Occurs when cancer cells become resistance during treatment
What is multiple resistance?
When tumor cells become cross-resistant to a wide rang of chemically dissimilar agents after exposure to a single drug
What are some things that can cause resistance?
Poor drug distribution
Sanctuary sites (esp brain)
Tumor cells not in cycle
Heterogeneity of tumor cells leading to clonal selection
Increased expression of MDR-1 gene would lead to what?
Increased level of P-glycoprotein