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Pharmacy > GERD/PUD > Flashcards

GERD/PUD Flashcards

1
Q

drugs that decrease LES pressure

A

ANTICHOLINERGICS
barbs, benzos, caffeine, ca channel blockers, dopamine, estrogen, ethanol, isoproterenol, narcotic, nicotine, nitrates, phentolamine, progesterone, theophylline

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2
Q

meds that are esophageal mucosa irritants

A

ALENDRONATE, aspirin, iron, NSAIDs, quinidine, potassium chloride

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3
Q

these three classes suppress gastric acid production

A

antacids
H2 receptor agonists
PPIs

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4
Q

these two drugs can be used as promotility therapy in the treatment of GERD

A

metoclopramide

bethanechol

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5
Q

this class rapidly neutralizes acid to raise intragastic pH (decrease pepsinogen, increase LES pressure)

A

antacids

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6
Q

this antacid includes alginigc acid, which adds a viscous layer acting as a barrier to reflux

A

Gaviscon

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7
Q

this class can cause diarrhea, constipation, or gas. Should not be given in anyone taking a calcium supplement or with renal dysfuntion

A

antacids

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8
Q

this class has many drug reactions. It alters gastric and urinary pH and provides a physical barrier to absorption. Be careful with quinolone, isoniazid, tetracycline, ferrous sulfate, quinidine, and sulfonylurea

A

antacids

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9
Q

Patients should not have to take these meds for over 14 days. If so, should be evaluated for Barret’s or upper GI pathology

A

antacids

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10
Q

this class reversibly inhibits H2 receptors on parietal cells

A

H2 receptor antagonists

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11
Q

this class is used for on-demand therapy for mild to moderate GERD symptoms. can be used before exercise or meals

A

H2 receptor antagonists

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12
Q

these drugs are rapidly and well absorbed after oral admin. they are largely excreted unchanged in the urine (adjust w renal impairment)

A

H2 receptor antagonists

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13
Q

this H2 RA is 90% bioavailable after first pass metabolism (others are 50%)

A

nizatidine

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14
Q

this class can cause HA, somnolence, fatigue, dizziness, constipation, or diarrhea. Thrombocytopenia is a rare but reversible SE

A

H2 receptor antagonist

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15
Q

this class interacts with CIMETIDINE to inhibit metab of warfarin, phenytoin, nifedipine, and propranolol. Also messes with ketoconazole, itraconazole, and ferrous sulfate (bc they require acidic environment for absorption)

A

H2 receptor antagonist

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16
Q

combine an antacid with what for more effective therapy?

A

H2 RA

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17
Q

this class eliminates symptoms and heals esophagitis more rapidly than other drugs, and should always be given before meals

A

PPIs

18
Q

this class inhibits the action of H, K, -ATPase

A

PPIs

19
Q

all drugs in this class are considered prodrugs- need the acidic environment to work

A

PPIs

20
Q

this class doesn’t usually cause ADRs, but can cause N/D/C, HA, dizznessiness, somnolence, perhaps a higher incidence of CAP

A

PPIs

21
Q

be cautious giving this class to patients with asthma, COPD, immunocompromise, young, old

A

PPIs

22
Q

which PPIs are metabolized by P450

A

OLEP

reduce metabolism of diazepam, phenytoin, warfarin

23
Q

this class works to reverse LES incompetence, decreased esophageal clearance, and delayed gastric emptying

A

promotility agents

24
Q

CNS effects of this class include drowsiness, irritability, extrapyramidal effects

A

promotility agents

25
Q

this drug is contraindicated in parkinsons, mechanical obs, use of dop ags, anticholinergics, and pheochromocytoma

A

metoclopramide

26
Q

this drug may increase acid production and is not well tolerated due to cholinergic side effects

A

bethanechol

27
Q

this promo agent can cause fatal cardiac dysrhythmia

A

cisapride

28
Q

this class of drug is not recommended for use except in very mild cases of GERD

A

mucosal protectants

29
Q

this drug polymerizes and cross links to form a sticky, yellow-white gel that adheres to atypical epithelial cells in the base of ulcer craters (when pH is below 4-administer before meals)

A

sucralfate

30
Q

this drug is effective at promoting motility in PUD and is more efficacious in duodenal rather than gastric ulcers. Can be used to prevent stress ulcers

A

sucralfate

31
Q

ADRS include constipation, dry mouth, and abdominal discomfort

A

sucralfate

32
Q

this drug should not be administered with agents that decrease acid. Reacts with phenytoin, digoxin, tetracycline, ketoconazole, fluroquinolone

A

sucralfate

33
Q

Is this effective for maintenance of GERD: full dose H2 receptor antagonist once daily?

A

NO. Use reduced dose PPIs (alternate day dosing or weekend therapy)

34
Q

treatment for zollinger-ellison syndrome

A

PPIs, chemo

35
Q

DOC for PUD

A

PPI

36
Q

3 dose regimen for PUD: PAC

A

PPI
Amoxicillin
Clarithromycin

37
Q

3 dose regimen for PUD: PMC

A

PPI
Metronidazole
Clarithromycin

38
Q

4 dose regimen PUD: PBMT

A

PPI
Bismuth subsalicylate
metronidazole
tetracycline

39
Q

this drug is beneficial for treating PUD: cytoprotection through enhanced secretion of mucous and HCO3, inhibit pepsin activity, antibacterial effects, promotes ulcer healing

A

bismuth subsalicylate

40
Q

this is a prostaglandin analogue that helps maintain the integrity of the gastroduodenal mucosal barrier and promotes healing

A

misoprostol

41
Q

this class is indicated for ulcer healing and prophylaxis w NSAID use

A

prostaglandin analogue

42
Q

this class can cause diarrhea or constipation. It is contraindicated in people with hypotension, breastfeeding, or pregnancy

A

prostaglandin analogue

Pharmacy (22 decks)

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