Gestational Trophoblastic Disease Flashcards Preview

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Flashcards in Gestational Trophoblastic Disease Deck (15)
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0
Q

Molar pregnancy

A

Abnl gestation, Villous edema, absence of amniotic membranes, no embryo, dec vascularity, Trophoblastic proliferation.

1
Q

Molar Pregnancy

A

Benign Hydatiform Mole: complete vs partial

Invasive Mole

Choriocarcinoma

Mole with coexisting fetus

2
Q

MC _____ origin

A

Paternal origin 46XX. Empty egg fertilized by single sperm that duplicates

3
Q

Clinical

A
Bleeding 1st trimester 
Passage grape like tissue
Size date discrepancy
Hyperemesis
HCG > 100,000
Dec MSAFP
Hyperthyroid, HTN, toxemia, resp distress
4
Q

HCG

A

> 100,000

5
Q

US 1st tri

A

Blighted Ovum, missed abortion, Echogenic mass in uterus

6
Q

US 2nd tri

A

Soft tissue echogenic mass with cystic spaces, snowflake appearance, Theca Lutein Cyst 50%

7
Q

Treatment

A

Evacuation, OCP 1 yr, serial HCG levels, HCG should drop 2-3 months unless Cancer. Chemo. Chest X-ray.

8
Q

Partial Mole

A

Associate with Triploidy 69xxx or 69xxy
Mole with coexisting fetus
Benign

9
Q

Invasive Mole/Chorioadenoma Destruens

A

Malignant
Not metastatic
Invades into myometrium of uterus
12-15% of molar pg turn into invasive mole

10
Q

Choriocarcinoma

A
Malignant
Metastatic 
50% from molar pg
50% from normal pg
75% mets to lung
11
Q

Complete mole

A

Has malignant potential

Diploid 46XX

12
Q

Highest incident

A

South East Asia

13
Q

Theca Lutein Cyst seen

A

50%

Multiseptated bilateral

14
Q

Choriocarcinoma MC mets to

A

Lungs