Gestational Trophoblastic Disease Flashcards Preview

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Flashcards in Gestational Trophoblastic Disease Deck (15)
0

Molar Pregnancy

Benign Hydatiform Mole: complete vs partial

Invasive Mole

Choriocarcinoma

Mole with coexisting fetus

1

Molar pregnancy

Abnl gestation, Villous edema, absence of amniotic membranes, no embryo, dec vascularity, Trophoblastic proliferation.

2

MC _____ origin

Paternal origin 46XX. Empty egg fertilized by single sperm that duplicates

3

Clinical

Bleeding 1st trimester
Passage grape like tissue
Size date discrepancy
Hyperemesis
HCG > 100,000
Dec MSAFP
Hyperthyroid, HTN, toxemia, resp distress

4

HCG

> 100,000

5

US 1st tri

Blighted Ovum, missed abortion, Echogenic mass in uterus

6

US 2nd tri

Soft tissue echogenic mass with cystic spaces, snowflake appearance, Theca Lutein Cyst 50%

7

Treatment

Evacuation, OCP 1 yr, serial HCG levels, HCG should drop 2-3 months unless Cancer. Chemo. Chest X-ray.

8

Partial Mole

Associate with Triploidy 69xxx or 69xxy
Mole with coexisting fetus
Benign

9

Invasive Mole/Chorioadenoma Destruens

Malignant
Not metastatic
Invades into myometrium of uterus
12-15% of molar pg turn into invasive mole

10

Choriocarcinoma

Malignant
Metastatic
50% from molar pg
50% from normal pg
75% mets to lung

11

Complete mole

Has malignant potential
Diploid 46XX

12

Highest incident

South East Asia

13

Theca Lutein Cyst seen

50%
Multiseptated bilateral

14

Choriocarcinoma MC mets to

Lungs