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Gluconeogenesis: Hydrolysis Reactions Flashcards

(16 cards)

1
Q

True or false: All of the reactions from PEP to FBP are freely reversible.

A

True

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2
Q

What enzyme catalyzes the conversion of FBP to F6P?

A

Fructose 1, 6-bisphosphatase (FBPase)

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3
Q

What type of reaction does FBPase catalyze?

A

A hydrolysis reaction of FBP to F6P

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4
Q

What enzyme catalyzes the conversion of G6P to glucose?

A

Glucose-6-phosphatase (G6Pase)

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5
Q

True or false: The enzyme that converts G6P to glucose is the also the enzyme used to convert glycogen to G6P.

A

True (glucose-6-phosphatase)

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6
Q

In what organs is the enzyme that converts G6P to glucose present?

A

Liver and kidneys

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7
Q

What kind of reaction is the conversion of G6P to glucose by G6Pase?

A

Hydrolysis reaction

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8
Q

True or false: FBPase and G6Pase convert ATP to ADP in their hydrolysis reactions.

A

False; they release inorganic phosphate (Pi)

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9
Q

What is the net energetic cost of converting 2 pyruvate to 1 glucose by gluconeogenesis?

A

6 ATP equivalents (2 in pyruvate carboxylase, 2 in PEP carboxykinase, and 2 in phosphoglycerate kinase)

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10
Q

What is the net ATP production of glycolysis?

A

2 ATP

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11
Q

What is the net cost of gluconeogenesis?

A

6 ATP equivalents

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12
Q

What is the net loss of cycling glucose to pyruvate then back to glucose?

A

4 ATP equivalents

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13
Q

What is the endpoint of gluconeogenesis?

A

Glucose

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14
Q

In what ways can the intermediates in gluconeogenesis be diverted from going to glucose?

A

1) Can be directed to the Pentose Phosphate Pathway for R5P production.
2) G6P can be converted to G1P for glycogen.

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15
Q

Where does gluconeogenesis end in most tissues besides the liver?

A

At Glucose-6-phosphate, which is then converted to glycogen.

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16
Q

Where is free glucose formed in liver tissue?

A

In the lumen of the endoplasmic reticulum.