Glycopeptides Flashcards Preview

A - MSRA Drugs [4] > Glycopeptides > Flashcards

Flashcards in Glycopeptides Deck (19)
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1
Q

Give 2 examples of glycopeptide antibiotics

A
  • Vancoymycin

- Teicoplanin

2
Q

What is the mechanism of action of glycopeptides?

A

Prevent elongation of peptide chain by inhibiting incorporation of NAMA and NAG subunits into chain

3
Q

Are glycopeptide antibiotics broad or narrow spectrum?

A

Narrow

4
Q

What are glycopeptide antibiotics effective against?

A

Aerobic and anaerobic gram +ve bacteria

5
Q

What are the routes of delivery of glycopeptide antibiotics?

A

PO

IV

6
Q

How should glycopeptide antibiotics be administered if given IV?

A

Slow administration

7
Q

Why should IV glycopeptides be administered slowly?

A

To avoid anaphylactoid reactions or red man syndrome

8
Q

Should vancomycin and teicoplanin be given orally in system infections?

A

No, as they are not well absorbed

9
Q

What are the indications for glycopeptides antibiotics?

A
  • Infections by gram -ve pathogens
  • C. Diff colitis
  • Endocarditis
  • Surgical prophylaxis
10
Q

When should glycopeptide antibiotics be given for surgical prophylaxis?

A

When high risk for MRSA

11
Q

Who should glycopeptide antibiotics be avoided in?

A

Patients with hearing loss

12
Q

Can glycopeptide antibiotics be given in renal impairment?

A

Yes, but reduce dose

13
Q

What drugs might vancomycin interact with?

A
  • Loop diuretics
  • Ciclosporin
  • Tacrolimus
  • Aminoglycosides
14
Q

What might happen if vancoymycin is given with the drugs I just said?

A

Increased risk of nephrotoxicity

15
Q

What should be done if there is prolonged administration of teicoplanin with other nephrotoxic or neurotoxic drugs?

A

Monitor renal and auditory function

16
Q

What monitoring is required with glycopeptide antibiotics?

A
  • Baseline U&Es and regular monitoring of renal function

- Vancoymycin levels

17
Q

What are the target vancomycin levels?

A

5-15mg/L trough or up to 20mg/L in severe infections

18
Q

What are the common side effects of glycopeptide antibiotics?

A
  • Ototoxicity
  • Nephrotoxicity
  • Pruritus
  • Rash
19
Q

What counselling is required in patients on glycopeptides?

A
  • Complete antibiotic course

- Ototoxicity