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Flashcards in Growth Factors Deck (10)
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1
Q

2 Main Functions of Neurotrophins

A

Increase survival of neurons and regulate formation/maintenance of synapses

2
Q

4 Ntrophins and Their Rs

A

NGF binds TrkA
BDNF binds TrkB
NT-3 binds TrkC (also A and B)
NT-4/5 binds TrkB

3
Q

Major Point about Rs in PNS

A

Some peripheral neurons/functions depend on one specific Trk, so if you knock out one might lose altogether

4
Q

p75 R

A

Initiates cell death if binds Ntrophin or pro-form, or higher affinity for cell survival when complexed w/ Trk

5
Q

Constitutive Pathway

A

Usually NGF and developmental, pro-protein matures, cleaved by furin, and targeted to constitutive release vesicles. Carried down postsyn retrograde to cell body to stimulate growth cascades

6
Q

Regulated Pathway

A

Usually BDNF and mature, resistant to furin, pro packaged in secretory granules that accumulate at PM for depol release (can be cleaved by pro-prot convertases there or after release). Also transported to axon terminals of producing cell, and helps there? So autocrine or paracrine

7
Q

3 Mechs BDNF Increases Synaptic Plasticity

A

Increases # of synapses, conductance of Rs, and expression of Rs

8
Q

BDNF Val66Met Polymorphism

A

If Met there instead of Val, working memory is worse, in animals has shown lower BDNF levels

9
Q

Chronic Stress Peripheral and 3 Central Effects

A

Increase peripheral levels of NGF, decrease central levels of NGF, BDNF, and NT-3

10
Q

Aging Effects

A

Ntrophin Levels same, but Pro levels go up, so maybe p75 causes increased death